| Autor: |
Savaş EM; Department of Internal Medicine, Hacettepe University School of Medicine, Ankara, Turkey., Oğuz SH; Division of Endocrinology and Metabolism, Department of Internal Medicine, Hacettepe University School of Medicine, Ankara, Turkey., Samadi A; Department of Medical Biochemistry, Hacettepe University School of Medicine, Ankara, Turkey., Yılmaz Işıkhan S; Department of Biostatistics, Hacettepe University School of Medicine, Ankara, Turkey., Ünlütürk U; Division of Endocrinology and Metabolism, Department of Internal Medicine, Hacettepe University School of Medicine, Ankara, Turkey., Lay İ; Department of Medical Biochemistry, Hacettepe University School of Medicine, Ankara, Turkey., Gürlek A; Division of Endocrinology and Metabolism, Department of Internal Medicine, Hacettepe University School of Medicine, Ankara, Turkey. |
| Jazyk: |
angličtina |
| Zdroj: |
Metabolic syndrome and related disorders [Metab Syndr Relat Disord] 2020 May; Vol. 18 (4), pp. 197-205. Date of Electronic Publication: 2020 Feb 25. |
| DOI: |
10.1089/met.2019.0074 |
| Abstrakt: |
Background: Apoptosis inhibitor of macrophage (AIM) and monocyte chemotactic protein-1 (MCP-1) are molecules that cause migration of M1 macrophages to visceral adipocytes, which is the first step in development of metabolic syndrome. The aim of this study is to evaluate the status of AIM and MCP-1 in metabolic syndrome and to investigate their use as biomarkers. Methods: Forty metabolic syndrome patients and 40 healthy individuals were enrolled in the study. Serum AIM, MCP-1, and C-reactive protein (CRP) levels were measured by enzyme-linked immunosorbent assay. Results: AIM, MCP-1, and CRP levels were significantly higher in the metabolic syndrome group ( P < 0.01, P < 0.01, and P < 0.05, respectively). There was a positive correlation of serum AIM, MCP-1, and CRP levels with waist circumference ( r = 0.480, r = 0.663, and r = 0.418, respectively; P < 0.01). Receiver operating characteristic (ROC) curve analyses revealed AIM, MCP-1, and CRP cutoff points as 2383.7 ng/mL, 172.8 pg/mL, and 0.366 mg/dL, which could be used in the diagnosis of metabolic syndrome with highest sensitivity and specificity. In the logistic regression model, including age, AIM, CRP, and MCP-1 as covariates, having serum AIM and CRP levels above cutoffs were significant independent predictors for metabolic syndrome (odds ratios 13.8 and 21.3), whereas the serum MCP-1 level was not a significant independent predictor, although the odds ratio was 2.6 ( P = 0.193). Conclusions: These results suggest that AIM and MCP-1 may play a role in the pathogenesis of metabolic syndrome. AIM and CRP levels may be used as biomarkers in the diagnosis of metabolic syndrome. Although MCP-1 is not an independent predictor, its elevation in metabolic syndrome is noteworthy, which warrants further analyses in larger groups. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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