| Autor: |
Pysarevska S; Life Safety Department, Ivan Franko National University of Lviv, Lviv, Ukraine., Plotycya S; Analytical Chemistry Department, Ivan Franko National University of Lviv, Lviv, Ukraine.; State Scientific-Research Control Institute of Veterinary Medicinal Products and Feed Additives, Lviv, Ukraine., Dubenska L; Analytical Chemistry Department, Ivan Franko National University of Lviv, Lviv, Ukraine. |
| Jazyk: |
angličtina |
| Zdroj: |
Critical reviews in analytical chemistry [Crit Rev Anal Chem] 2021; Vol. 51 (4), pp. 339-352. Date of Electronic Publication: 2020 Feb 25. |
| DOI: |
10.1080/10408347.2020.1729691 |
| Abstrakt: |
Local anesthetics (LAs) are widely used in anesthesiology, ophthalmology, and otolaryngology as well as for treatment of chronic and oncological pain. However, anesthetics can cause adverse effects up to lethal ones. In this work, we cited reviews on chromatographic and spectroscopic methods of local anesthetics determination published earlier, and the main purpose was to review the possibilities and advantages of voltammetric methods used for the LAs determination. The electrochemical behavior, mechanism of LAs transformation on the various working electrodes and analytical parameters of voltammetric methods used for their determination were reviewed in the work. Vast majority of these methods were developed for the most widely used anesthetics in medicine like benzocaine, lidocaine and procaine. Special attention was paid to possible mechanisms of electrochemical oxidation and in some cases reduction of LAs or their derivatives. Voltammetry is used for the determination of LAs in pharmaceutical formulations and in biological fluids. The analytical characteristics in terms of sensitivity, selectivity, reproducibility also were discussed in the article. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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