| Autor: |
Rosenquist NA; School of Community Health Sciences, University of Nevada, Reno, NV, USA. nreavy@nevada.unr.edu., Metcalf WJ; Renown Institute for Health Innovation, Reno, NV, USA.; Desert Research Institute, Reno, NV, USA., Ryu SY; School of Community Health Sciences, University of Nevada, Reno, NV, USA., Rutledge A; University of Nevada School of Medicine, Reno, NV, USA., Coppes MJ; Renown Institute for Health Innovation, Reno, NV, USA.; University of Nevada School of Medicine, Reno, NV, USA.; Renown Children's Hospital, Reno, NV, USA., Grzymski JJ; Renown Institute for Health Innovation, Reno, NV, USA.; Desert Research Institute, Reno, NV, USA., Strickland MJ; School of Community Health Sciences, University of Nevada, Reno, NV, USA.; University of Nevada School of Medicine, Reno, NV, USA., Darrow LA; School of Community Health Sciences, University of Nevada, Reno, NV, USA.; University of Nevada School of Medicine, Reno, NV, USA. |
| Abstrakt: |
Acute effects of outdoor air pollution on asthma exacerbations may vary by asthma phenotype (allergic vs nonallergic). Associations of ambient PM 2.5 and ozone concentrations with acute asthma visits (office, urgent, emergency, and hospitalization) were investigated using electronic medical records. International Classification of Disease codes were used to identify asthmatics, and classify them based on the presence or absence of an allergic comorbidity in their medical records. Daily 24-h average PM 2.5 , 8-h maximum ozone, and mean temperature were obtained from a centralized monitor. Using a time-stratified case-crossover approach, pollutant concentrations were modeled using moving averages and distributed lag nonlinear models (lag 0-6) to examine lag associations and nonlinear concentration-response. The adjusted odds ratios for a 10 µg/m 3 increase in 3-day moving average (lag 0-2) PM 2.5 in the two-pollutant models among patients with and without allergic comorbidities were 1.10 (95% confidence interval [CI]: 1.07, 1.13) and 1.05 (95% CI: 1.02, 1.09), respectively; and for a 20 ppb increase in 3-day moving average (lag 0-2) ozone were 1.08 (95% CI: 1.02, 1.14) and 1.00 (95% CI: 0.95, 1.05), respectively. Estimated odds ratios among patients with allergic comorbidities were consistently higher across age, sex, and temperature categories. Asthmatics with an allergic comorbidity may be more susceptible to ambient PM 2.5 and ozone. |
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