Ovariectomy provokes inflammatory and cardiovascular effects of endotoxemia in rats: Dissimilar benefits of hormonal supplements.
Autor: | El-Lakany MA; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt., Fouda MA; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt., El-Gowelli HM; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt., El-Mas MM; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt. Electronic address: mahmoud.elmas@alexu.edu.eg. |
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Jazyk: | angličtina |
Zdroj: | Toxicology and applied pharmacology [Toxicol Appl Pharmacol] 2020 Apr 15; Vol. 393, pp. 114928. Date of Electronic Publication: 2020 Feb 21. |
DOI: | 10.1016/j.taap.2020.114928 |
Abstrakt: | The female gender is protected against immunological complications of endotoxemia. Here we investigated whether gonadal hormone depletion by ovariectomy (OVX) uncovers inflammatory and cardiovascular effects of endotoxemia and whether these effects are reversed by hormone replacement therapies. Changes in inflammatory cytokines, blood pressure (BP), left ventricular (LV) function, and cardiac autonomic activity caused by lipopolysaccharide (LPS) in conscious female rats with different hormonal states were determined. In contrast to no effects in sham-operated females, treatment of OVX rats with LPS (i) decreased BP, (ii) increased spectral low-frequency/high-frequency ratio of HRV, denoting enhanced cardiac sympathetic dominance, (iii) attenuated reflex tachycardic responses to sodium nitroprusside, and (iv) increased systolic contractility (dP/dt Competing Interests: Declaration of Competing Interest None. (Copyright © 2020 Elsevier Inc. All rights reserved.) |
Databáze: | MEDLINE |
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