| Autor: |
Bissim SM; Chemistry Laboratory, Faculty of Sciences, University of Douala, Douala, Cameroon.; H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences (ICCBS), University of Karachi, Karachi, Pakistan., Kenmogne SB; Chemistry Laboratory, Faculty of Sciences, University of Douala, Douala, Cameroon., Lobe JS; Chemistry Laboratory, Faculty of Sciences, University of Douala, Douala, Cameroon., Atangana AF; Chemistry Laboratory, Faculty of Sciences, University of Douala, Douala, Cameroon., Bissoue AN; Chemistry Laboratory, Faculty of Sciences, University of Douala, Douala, Cameroon., Langat MK; Jodrell Laboratory, Natural Capital and Plant Health Department, Royal Botanic Gardens, Kew, Richmond, Surrey, UK., Isyaka SM; Natural Products Research Group, Department of Chemistry, Faculty of Engineering and Physical Sciences, University of Surrey, Guildford, UK., Lateef M; Pakistan Council of Scientific and Industrial Research, Karachi, Pakistan.; Multi-Disciplinary Research Laboratory, Bahria University Medical and Dental College, Karachi, Pakistan., Emmanuel NH; Chemistry Laboratory, Faculty of Sciences, University of Douala, Douala, Cameroon., Wansi JD; Chemistry Laboratory, Faculty of Sciences, University of Douala, Douala, Cameroon., Ali MS; H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences (ICCBS), University of Karachi, Karachi, Pakistan., Waffo AFK; Chemistry Laboratory, Faculty of Sciences, University of Douala, Douala, Cameroon. |
| Abstrakt: |
We report the chemistry and biological activities of a Cameroonian Citrus clementina Hort. Ex Tanaka, a vegetatively propagated species. The compounds isolated from this plant were determined to be the known 5-hydroxy-6,7,8,3',4'-pentamethoxyflavone ( 1 ), tangerine ( 3 ), nobilletin ( 4 ), 5,7,8,4'-tetramethoxyflavone ( 5 ), citracridone I ( 6 ), 5-hydroxynoracronycine ( 7 ), citracridone III ( 8 ), xanthyletin ( 10 ), suberosin ( 9 ), E -suberenol ( 11 ), E -methoxysuberenol ( 13 ), 6-formylumbelliferone ( 12 ), aurantiamide acetate ( 2 ), limonin ( 14 ), stigmasterol, β -sitosterol and β -sitosterol-3- O - β -D-glucoside. The structures of the compounds were established on the basis of their NMR spectroscopic data and comparison with published data. Methanol leaf extract and compounds 1 , 2 , 4 , 6 , 7 and 10 were evaluated for their anti-inflammatory, antioxidant, urease and anti-diabetic effects. Compound 10 showed antioxidant activity, anti-inflammatory effect, urease activity and anti-diabetic activity with IC 50 values of 47.3 µM, 33.5 µM, 25.2 µM and 33.9 µM respectively, values that were comparable to the respective positive standards. |
