Assessing the Autonomic and Behavioral Effects of Passive Motion in Rats using Elevator Vertical Motion and Ferris-Wheel Rotation.

Autor: Manno FAM; School of Biomedical Engineering, Faculty of Engineering, University of Sydney; Department of Physics, City University of Hong Kong., Pan L; Department of Nautical Injury Prevention, Faculty of Navy Medicine, Second Military Medical University., Mao Y; Department of Nautical Injury Prevention, Faculty of Navy Medicine, Second Military Medical University., Su Y; Department of Nautical Injury Prevention, Faculty of Navy Medicine, Second Military Medical University., Manno SHC; Department of Physics, City University of Hong Kong; State Key Laboratory of Marine Pollution (SKLMP), City University of Hong Kong; Department of Biomedical Sciences, College of Veterinary Medicine and Life Sciences, City University of Hong Kong., Cheng SH; State Key Laboratory of Marine Pollution (SKLMP), City University of Hong Kong; Department of Biomedical Sciences, College of Veterinary Medicine and Life Sciences, City University of Hong Kong; Department of Materials Science and Engineering, City University of Hong Kong., Lau C; Department of Physics, City University of Hong Kong; condon.lau@cityu.edu.hk., Cai Y; Department of Nautical Injury Prevention, Faculty of Navy Medicine, Second Military Medical University; yilingcai1@sohu.com.
Jazyk: angličtina
Zdroj: Journal of visualized experiments : JoVE [J Vis Exp] 2020 Feb 07 (156). Date of Electronic Publication: 2020 Feb 07.
DOI: 10.3791/59837
Abstrakt: The overall goal of this study is to assess the autonomic and behavioral effects of passive motion in rodents using the elevator vertical motion and Ferris-wheel rotation devices. These assays can help confirm the integrity and normal functioning of the autonomic nervous system. They are coupled to quantitative measures based on defecation counting, open-field examination, and balance beam crossing. The advantages of these assays are their simplicity, reproducibility, and quantitative behavioral measures. The limitations of these assays are that the autonomic reactions could be epiphenomena of non-vestibular disorders and that a functioning vestibular system is required. Examination of disorders such as motion sickness will be greatly aided by the detailed procedures of these assays.
Databáze: MEDLINE
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