Oxidative Stress and Gut-Derived Lipopolysaccharides in Neurodegenerative Disease: Role of NOX2.

Autor: Loffredo L; Department of Internal Medicine and Medical Specialties, Sapienza University of Rome, Italy., Ettorre E; Department of Cardiovascular, Respiratory, Nephrologic, Anesthesiologic and Geriatric Sciences, Division of Gerontology, Sapienza University of Rome, Rome, Italy., Zicari AM; Department of Pediatrics, Sapienza University of Rome, Italy., Inghilleri M; Department of Human Neuroscience, Sapienza University, Rome, Italy., Nocella C; Department of Medical-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Latina, Italy.; Cardiocentro Mediterranea, Napoli, Italy., Perri L; Department of Internal Medicine and Medical Specialties, Sapienza University of Rome, Italy., Spalice A; Department of Pediatrics, Sapienza University of Rome, Italy., Fossati C; Department of Movement, Human and Health Sciences, University of Rome 'Foro Italico', Italy., De Lucia MC; UTNA, IRCCS Neuromed Pozzilli, Isernia, Italy., Pigozzi F; Department of Movement, Human and Health Sciences, University of Rome 'Foro Italico', Italy., Cacciafesta M; Department of Cardiovascular, Respiratory, Nephrologic, Anesthesiologic and Geriatric Sciences, Division of Gerontology, Sapienza University of Rome, Rome, Italy., Violi F; Department of Internal Medicine and Medical Specialties, Sapienza University of Rome, Italy.; Cardiocentro Mediterranea, Napoli, Italy., Carnevale R; Department of Medical-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Latina, Italy.; Cardiocentro Mediterranea, Napoli, Italy.
Jazyk: angličtina
Zdroj: Oxidative medicine and cellular longevity [Oxid Med Cell Longev] 2020 Jan 31; Vol. 2020, pp. 8630275. Date of Electronic Publication: 2020 Jan 31 (Print Publication: 2020).
DOI: 10.1155/2020/8630275
Abstrakt: Background: Neurodegenerative diseases (ND) as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis represent a growing cause of disability in the developed countries. The underlying physiopathology is still unclear. Several lines of evidence suggest a role for oxidative stress and NADPH oxidase 2 (NOX2) in the neuropathological pathways that lead to ND. Furthermore, recent studies hypothesized a role for gut microbiota in the neuroinflammation; in particular, lipopolysaccharide (LPS) derived from Gram-negative bacteria in the gut is believed to play a role in causing ND by increase of oxidative stress and inflammation. The aim of this study was to assess NOX2 activity as well as serum 8-iso-prostaglandin F2 α (8-iso-PGF2 α (8-iso-PGF2.
Methods: One hundred and twenty-eight consecutive subjects, including 64 ND patients and 64 controls (CT) matched for age and gender, were recruited. A cross-sectional study was performed to compare serum activity of soluble NOX2-dp (sNOX2-dp), blood levels of isoprostanes, serum H 2 O 2 , and LPS in these two groups. Serum zonulin was used to assess gut permeability.
Results: Compared with CT, ND patients had higher values of sNOX2-dp, 8-iso-PGF2 α (8-iso-PGF2 p < 0.001), zonulin (Rs = 0.411; p < 0.001), zonulin (Rs = 0.411; p < 0.001), zonulin (Rs = 0.411; α (8-iso-PGF2 p < 0.001), zonulin (Rs = 0.411; p < 0.001), zonulin (Rs = 0.411; α (8-iso-PGF2 p < 0.001), zonulin (Rs = 0.411; β , 0.459; p < 0.001), zonulin (Rs = 0.411; α (8-iso-PGF2 β , 0.459; p < 0.001), zonulin (Rs = 0.411; R 2 = 57%).
Conclusion: This study provides the first report attesting that patients with ND have high NOX2 activation that could be potentially implicated in the process of neuroinflammation.
Competing Interests: All the authors have no conflicts of interest to disclose.
(Copyright © 2020 Lorenzo Loffredo et al.)
Databáze: MEDLINE
Externí odkaz: