Dental Stem Cell-Derived Secretome/Conditioned Medium: The Future for Regenerative Therapeutic Applications.

Autor: El Moshy S; Oral Biology Department, Faculty of Dentistry, Cairo University, Cairo, Egypt.; Stem cells and Tissue Engineering Research Group, Faculty of Dentistry, Cairo University, Cairo, Egypt., Radwan IA; Oral Biology Department, Faculty of Dentistry, Cairo University, Cairo, Egypt.; Stem cells and Tissue Engineering Research Group, Faculty of Dentistry, Cairo University, Cairo, Egypt., Rady D; Oral Biology Department, Faculty of Dentistry, Cairo University, Cairo, Egypt.; Stem cells and Tissue Engineering Research Group, Faculty of Dentistry, Cairo University, Cairo, Egypt., Abbass MMS; Oral Biology Department, Faculty of Dentistry, Cairo University, Cairo, Egypt.; Stem cells and Tissue Engineering Research Group, Faculty of Dentistry, Cairo University, Cairo, Egypt., El-Rashidy AA; Stem cells and Tissue Engineering Research Group, Faculty of Dentistry, Cairo University, Cairo, Egypt.; Biomaterials Department, Faculty of Dentistry, Cairo University, Cairo, Egypt., Sadek KM; Stem cells and Tissue Engineering Research Group, Faculty of Dentistry, Cairo University, Cairo, Egypt.; Biomaterials Department, Faculty of Dentistry, Cairo University, Cairo, Egypt., Dörfer CE; Clinic for Conservative Dentistry and Periodontology, School of Dental Medicine, Christian Albrechts University, Kiel, Germany., Fawzy El-Sayed KM; Stem cells and Tissue Engineering Research Group, Faculty of Dentistry, Cairo University, Cairo, Egypt.; Clinic for Conservative Dentistry and Periodontology, School of Dental Medicine, Christian Albrechts University, Kiel, Germany.; Oral Medicine and Periodontology Department, Faculty of Dentistry, Cairo University, Cairo, Egypt.
Jazyk: angličtina
Zdroj: Stem cells international [Stem Cells Int] 2020 Jan 31; Vol. 2020, pp. 7593402. Date of Electronic Publication: 2020 Jan 31 (Print Publication: 2020).
DOI: 10.1155/2020/7593402
Abstrakt: Regenerative medicine literature has proposed mesenchymal stem/progenitor cell- (MSC-) mediated therapeutic approaches for their great potential in managing various diseases and tissue defects. Dental MSCs represent promising alternatives to nondental MSCs, owing to their ease of harvesting with minimally invasive procedures. Their mechanism of action has been attributed to their cell-to-cell contacts as well as to the paracrine effect of their secreted factors, namely, secretome. In this context, dental MSC-derived secretome/conditioned medium could represent a unique cell-free regenerative and therapeutic approach, with fascinating advantages over parent cells. This article reviews the application of different populations of dental MSC secretome/conditioned medium in in vitro and in vivo animal models, highlights their significant implementation in treating different tissue' diseases, and clarifies the significant bioactive molecules involved in their regenerative potential. The analysis of these recent studies clearly indicate that dental MSCs' secretome/conditioned medium could be effective in treating neural injuries, for dental tissue regeneration, in repairing bone defects, and in managing cardiovascular diseases, diabetes mellitus, hepatic regeneration, and skin injuries, through regulating anti-inflammatory, antiapoptotic, angiogenic, osteogenic, and neurogenic mediators.
Competing Interests: The authors declare that they have no conflicts of interest.
(Copyright © 2020 Sara El Moshy et al.)
Databáze: MEDLINE
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