[Induction of the antileukemic activity in nonimmune allogeneic splenocytes using spleen hemoregulators].

Autor: Svirnovskiĭ AI, Shimanskaia TV, Bakun AV, Ageĭchik VM
Jazyk: ruština
Zdroj: Eksperimental'naia onkologiia [Eksp Onkol] 1988; Vol. 10 (5), pp. 57-61.
Abstrakt: The leukemic mice treated with cyclophosphamide were injected twice a week with the allogenic splenocytes treated for 4 h with the substance isolated from the calf spleen. The leukemia growth inhibition was observed. Syngenic splenocytes were inactive. Allogenic but not syngenic splenocytes manifested a certain antileukemic activity observed in the Winn neutralization and 51Cr release tests, however this activity did not correlate quantitatively with more pronounced antileukemic action of cells in vivo.
Databáze: MEDLINE