Antidiabetic activity of Musa x paradisiaca extracts in streptozotocin-induced diabetic rats and chemical characterization by HPLC-DAD-MS.

Autor: Vilhena RO; Departamento de Farmácia, Universidade Federal do Paraná, Curitiba, PR, Brazil. Electronic address: raquel.vilhena@hotmail.com., Figueiredo ID; Departamento de Análises Clínicas, Universidade Estadual Paulista Júlio de Mesquita Filho, Araraquara, SP, Brazil. Electronic address: delboneingrid@gmail.com., Baviera AM; Departamento de Análises Clínicas, Universidade Estadual Paulista Júlio de Mesquita Filho, Araraquara, SP, Brazil. Electronic address: bavieraam@gmail.com., Silva DB; Laboratório de Produtos Naturais e Espectrometria de Massas, Faculdade de Ciências Farmacêuticas, Alimentos e Nutrição, Universidade Federal do Mato Grosso do Sul, Campo Grande, MS, Brazil. Electronic address: enisebrentan@gmail.com., Marson BM; Departamento de Farmácia, Universidade Federal do Paraná, Curitiba, PR, Brazil. Electronic address: bmarson@gmail.com., Oliveira JA; Departamento de Análises Clínicas, Universidade Estadual Paulista Júlio de Mesquita Filho, Araraquara, SP, Brazil. Electronic address: jonataaugustooliveira@gmail.com., Peccinini RG; Departamento de Princípios Ativos Naturais e Toxicologia, Universidade Estadual Paulista Júlio de Mesquita Filho, Araraquara, SP, Brazil. Electronic address: peccinin@fcfar.unesp.br., Borges IK; Departamento de Ciências Patológicas, Universidade Estadual de Londrina, Londrina, PR, Brazil. Electronic address: belekaza@gmail.com., Pontarolo R; Departamento de Farmácia, Universidade Federal do Paraná, Curitiba, PR, Brazil. Electronic address: pontarolo@ufpr.br.
Jazyk: angličtina
Zdroj: Journal of ethnopharmacology [J Ethnopharmacol] 2020 May 23; Vol. 254, pp. 112666. Date of Electronic Publication: 2020 Feb 19.
DOI: 10.1016/j.jep.2020.112666
Abstrakt: Ethnopharmacological Relevance: The Musa x paradisiaca L. inflorescence, known as banana blossom or banana heart, is used in traditional medicine for the treatment of diabetes mellitus.
Aim of the Study: The aim of the study was to investigate the antidiabetic activity of aqueous extracts and fractions prepared from the bracts and flowers of Musa x paradisiaca in streptozotocin (STZ)-induced diabetic rats and to chemically characterize the extracts.
Materials and Methods: Standard aqueous extracts of the flowers, bracts, and their fractions were prepared and their chemical composition was determined tentatively by high-performance liquid chromatography coupled to diode-array detection and mass spectrometry (HPLC-DAD-MS). Changes in fasting glycemia and oral glucose tolerance were evaluated in STZ-induced diabetic rats (n = 8) treated with aqueous extracts of Musa x paradisiaca (200 mg/kg) for 20 days.
Results: Chemical analyses detected 21 compounds and 17 metabolites were identified, among which were glycosylated and acetylated phenylpropanoids of p-coumaric acid and caffeic acid, as well as a glycosylated flavonol and anthocyanins. Following 15 days of treatment, the bract aqueous extracts and the methanolic fraction of the flower had significant effects on the glycemic profile after glucose load in diabetic rats as compared with the untreated diabetic group.
Conclusions: The results of the present study show the antidiabetic potential of extracts of the flowers and bracts of M. x paradisiaca.
Competing Interests: Declaration of competing interest The authors have no conflicts of interest.
(Copyright © 2020 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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