New evidence of bovine leukemia virus circulating in Myanmar cattle through epidemiological and molecular characterization.

Autor: Moe KK; Nakamura Laboratory, Baton Zone Program, RIKEN Cluster for Science, Technology and Innovation Hub, Wako, Saitama, Japan.; Department of Pathology and Microbiology, University of Veterinary Science, Yezin, Nay Pyi Taw, Myanmar., Polat M; Nakamura Laboratory, Baton Zone Program, RIKEN Cluster for Science, Technology and Innovation Hub, Wako, Saitama, Japan., Borjigin L; Nakamura Laboratory, Baton Zone Program, RIKEN Cluster for Science, Technology and Innovation Hub, Wako, Saitama, Japan., Matsuura R; Laboratory of Viral Infectious Diseases, Department of Computational Biology and Medical Sciences, Graduate School of Frontier Science, The University of Tokyo, Wako, Saitama, Japan., Hein ST; Department of Anatomy, University of Veterinary Science, Yezin, Nay Pyi Taw, Myanmar., Moe HH; Department of Genetics and Animal Breeding, University of Veterinary Science, Yezin, Nay Pyi Taw, Myanmar., Aida Y; Nakamura Laboratory, Baton Zone Program, RIKEN Cluster for Science, Technology and Innovation Hub, Wako, Saitama, Japan.; Laboratory of Viral Infectious Diseases, Department of Computational Biology and Medical Sciences, Graduate School of Frontier Science, The University of Tokyo, Wako, Saitama, Japan.
Jazyk: angličtina
Zdroj: PloS one [PLoS One] 2020 Feb 21; Vol. 15 (2), pp. e0229126. Date of Electronic Publication: 2020 Feb 21 (Print Publication: 2020).
DOI: 10.1371/journal.pone.0229126
Abstrakt: Bovine leukemia virus (BLV) is the etiological agent of enzootic bovine leukosis, which is the most common neoplastic disease of cattle. BLV infects cattle worldwide and causes serious problems for the cattle industry. In this study, we examined the prevalence of BLV infection and the distribution of BLV genotypes in cattle in the northern, central, and southern parts of Myanmar. The prevalence of BLV infection among Myanmar cattle (37.04%) in this study was markedly higher than the prevalence (9.1%) observed in our earlier study in which BLV was detected from the limited number of cattle only from a small area of Myanmar. Phylogenetic analysis of partial env-gp51 sequence of the isolated BLV strains revealed that there are at least three BLV genotypes (genotype-1, genotype-6, and genotype-10) in Myanmar, which have also been detected in the neighboring countries. We performed this study to estimate the BLV proviral load, which is a major diagnosis index for determining the virus transmission risk. The cattle of the three test regions with warm, wet, and humid climatic conditions (upper Sagaing, Yangon, and Kayin) exhibited a high mean proviral load, while cattle of three other regions with low annual rainfall and very high temperature (Mandalay, Magway, and upper Bago) exhibited a low mean proviral load. Further, the level of proviral load and the prevalence of BLV infection in Myanmar native cattle (N = 235) were lower than that in the hybrid cattle (Holstein Friesian × Myanmar native) (N = 62). We also observed that the cattle with high risk for BLV transmission, which have high proviral load, may enhance the BLV infection rate. Hence, to control BLV transmission, it is necessary to eliminate these cattle with high-risk for BLV transmission and to diagnose BLV provirus in cattle in the remaining regions/states of Myanmar sharing a boundary with neighboring countries.
Competing Interests: The authors have declared that no competing interests exist.
Databáze: MEDLINE
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