Spatial-Temporal Dynamics of Hepatitis E Virus Infection in Foxes ( Vulpes vulpes ) in Federal State of Brandenburg, Germany, 1993-2012.

Autor:	Eiden M; Institute for Novel and Emerging Infectious Diseases, Friedrich-Loeffler-Institut, Greifswald-Insel Riems, Germany., Dähnert L; Institute for Novel and Emerging Infectious Diseases, Friedrich-Loeffler-Institut, Greifswald-Insel Riems, Germany., Spoerel S; Institute for Novel and Emerging Infectious Diseases, Friedrich-Loeffler-Institut, Greifswald-Insel Riems, Germany.; Tierarztpraxis Dr. Kindler, Wiesbaden, Germany., Vina-Rodriguez A; Institute for Novel and Emerging Infectious Diseases, Friedrich-Loeffler-Institut, Greifswald-Insel Riems, Germany., Schröder R; Institute of Epidemiology, Friedrich-Loeffler-Institut, Greifswald-Insel Riems, Germany., Conraths FJ; Institute of Epidemiology, Friedrich-Loeffler-Institut, Greifswald-Insel Riems, Germany., Groschup MH; Institute for Novel and Emerging Infectious Diseases, Friedrich-Loeffler-Institut, Greifswald-Insel Riems, Germany.
Jazyk:	angličtina
Zdroj:	Frontiers in microbiology [Front Microbiol] 2020 Jan 31; Vol. 11, pp. 115. Date of Electronic Publication: 2020 Jan 31 (Print Publication: 2020).
DOI:	10.3389/fmicb.2020.00115
Abstrakt:	Hepatitis E virus (HEV) is the main course for acute hepatitis in humans throughout the world. Human associated genotypes 1 and 2 as well as zoonotic genotypes 3 and 4 are grouped in the species Orthohepevirus A . In addition, a large variety of HEV-related viruses has been found in vertebrates including carnivores, rats, bats, and chickens, which were classified in species Orthohepevirus B-D . In 2015, partial genome sequences of a novel hepevirus were detected in feces of red foxes ( Vulpes vulpes ). However, no further information about virus circulation and the prevalence in foxes was available. We therefore assayed a unique panel of 880 transudates, which was collected from red foxes over 19 years (1993-2012) in Brandenburg, Germany, for HEV-related viral RNA and antibodies. Our results demonstrate a high antibody prevalence of HEV in red foxes, which oscillated annually between 40 and 100%. Molecular screening of the transudates revealed only a single RNA-positive sample, which was assigned to the carnivore species Orthohepevirus C based on the amplified partial sequence. These data indicate that the virus is circulating widely in the fox population and that foxes are carriers of this virus. (Copyright © 2020 Eiden, Dähnert, Spoerel, Vina-Rodriguez, Schröder, Conraths and Groschup.)
Databáze:	MEDLINE
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