In Patients Over 50 Years, Increased Age Is Associated With Decreased Odds of Documented Loss of Consciousness After a Concussion.

Autor:	Orlando A; Department of Trauma Research, Swedish Medical Center, Englewood, CO, United States.; Department of Trauma Research, Penrose Hospital, Colorado Springs, CO, United States.; Department of Trauma Research, Medical City Plano, Plano, TX, United States.; Department of Trauma Research, St. Anthony Hospital, Lakewood, CO, United States.; Department of Trauma Research, Research Medical Center, Kansas City, MO, United States.; Department of Trauma Research, Wesley Medical Center, Wichita, KS, United States., Rubin B; Department of Neurosurgery, Swedish Medical Center, Englewood, CO, United States., Panchal R; Department of Neurosurgery, Medical City Plano, Plano, TX, United States., Tanner A 2nd; Department of Trauma Services, Penrose Hospital, Colorado Springs, CO, United States., Hudson J; Department of Neurosurgery, St. Anthony Hospital, Lakewood, CO, United States., Harken K; Department of Trauma Services, Research Medical Center, Kansas City, MO, United States., Madayag R; Department of Trauma Services, St. Anthony Hospital, Lakewood, CO, United States., Berg G; Department of Trauma Research, Wesley Medical Center, Wichita, KS, United States., Bar-Or D; Department of Trauma Research, Swedish Medical Center, Englewood, CO, United States.; Department of Trauma Research, Penrose Hospital, Colorado Springs, CO, United States.; Department of Trauma Research, Medical City Plano, Plano, TX, United States.; Department of Trauma Research, St. Anthony Hospital, Lakewood, CO, United States.; Department of Trauma Research, Research Medical Center, Kansas City, MO, United States.; Department of Trauma Research, Wesley Medical Center, Wichita, KS, United States.
Jazyk:	angličtina
Zdroj:	Frontiers in neurology [Front Neurol] 2020 Jan 31; Vol. 11, pp. 39. Date of Electronic Publication: 2020 Jan 31 (Print Publication: 2020).
DOI:	10.3389/fneur.2020.00039
Abstrakt:	Background: Advanced aged adults have the highest rate of traumatic brain injury (TBI) related hospital admissions, compared to younger age groups. Data were published in 2014 indicating differential injury and neurological responses to a TBI by age categories. In a recent article examining patients with mTBI and isolated subdural hematoma, it was found that older patients had a decreased risk of documented loss of consciousness (LOC). The primary objective was to determine the extent to which the odds of documented LOC changes with increasing age in a population of older adults suffering an isolated concussion and uncomplicated mTBI. Methods: This was a retrospective study utilizing 6 years (2010-2015) of National Trauma Data Bank data. This study included patients with (1) diagnosis of concussion; (2) positive or negative loss of consciousness; (3) loss of consciousness durations no longer than 59 min or undefined; (4) age ≥50 years; (5) had a "fall" mechanism of injury; and (6) a valid emergency department Glasgow coma scale 13-15. We excluded patients (1) with any intracranial hemorrhage or intracranial injury of other and unspecified nature; (2) skull fracture; (3) an injury severity scale score >17; (4) a concussion with "unspecified" LOC (ICD-9: 850.9). Results: There were 7,466 patients included in the study; the median (IQR) age was 70 (60-80) years. The risk of documented LOC was 71% ( n = 5,319). An 80-year-old had 72% decreased odds of having a documented LOC, compared to a 50-year-old (OR = 0.28, 99.5%CI [0.23-0.34], P < 0.001). This association held when controlling for multiple demographic, comorbid, and clinical variables, and in sensitivity analyses. Conclusion: These nationwide data suggest that in patients aged ≥50 years, a significant inverse association exists between age and odds of documented LOC after sustaining a fall-related concussion. Additional studies are needed to validate these findings and to investigate the triad of age, documented LOC, and intracranial hemorrhage. Clinical diagnostic criteria relying on LOC might be at risk of being modified by the association between increasing age and decreasing odds of LOC. (Copyright © 2020 Orlando, Rubin, Panchal, Tanner, Hudson, Harken, Madayag, Berg and Bar-Or.)
Databáze:	MEDLINE
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