Wastewater-derived antagonistic activities of G protein-coupled receptor-acting pharmaceuticals in river water.

Autor: Ihara M; Research Center for Environmental Quality Management, Graduate School of Engineering, Shiga, Japan., Hanamoto S; Environment Preservation Center, Kanazawa University, Kanazawa, Ishikawa, Japan., Ihara MO; Research Center for Environmental Quality Management, Graduate School of Engineering, Shiga, Japan., Zhang H; Research Center for Environmental Quality Management, Graduate School of Engineering, Shiga, Japan., Tanaka H; Research Center for Environmental Quality Management, Graduate School of Engineering, Shiga, Japan.
Jazyk: angličtina
Zdroj: Journal of applied toxicology : JAT [J Appl Toxicol] 2020 Jul; Vol. 40 (7), pp. 908-917. Date of Electronic Publication: 2020 Feb 20.
DOI: 10.1002/jat.3952
Abstrakt: Pharmaceuticals are widely detected in aquatic environments, and their potential risks to aquatic species are of concern because they are designed to be biologically active. Here, we used an in vitro assay, called the transforming growth factor α shedding assay, to measure the biological activities of G protein-coupled receptor (GPCR)-acting pharmaceuticals present in river water and effluents from municipal wastewater treatment plants (WWTPs) in Japan from 2014 to 2016. Antagonistic activities against angiotensin (AT1), dopamine (D2), adrenergic (β1), acetylcholine (M1) and histamine (H1) receptors were detected in river water, and were stronger downstream than upstream owing to effluent from WWTPs along the river. Ozonation at one WWTP reduced these activities. Concentrations of sulpiride (D2 antagonist) could explain 73% of antagonistic activities against the D2 receptor; those of metoprolol, atenolol and propranolol (β1 antagonists) could explain 16% of activities against the β1 receptor; and those of pirenzepine (M1 antagonist) could explain 15% of activities against the M1 receptor. Therefore, other receptor antagonists also occur. GPCR-acting pharmaceuticals should be given more attention in environmental monitoring and toxicity testing.
(© 2020 John Wiley & Sons, Ltd.)
Databáze: MEDLINE
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