Pathophysiology of chronic peripheral ischemia: new perspectives.

Autor:	Signorelli SS; Department of Clinical and Experimental Medicine, University of Catania, University Hospital 'G. Rodolico', Catania, 95124, Italy., Vanella L; Department of Drug Science, University of Catania, Catania, Italy., Abraham NG; Departments of Medicine, Pharmacology and Gastroenterology, New York Medical College, Valhalla, NY, USA., Scuto S; Department of Clinical and Experimental Medicine, University of Catania, Catania, Italy., Marino E; Department of Clinical and Experimental Medicine, University of Catania, Catania, Italy., Rocic P; Departments of Medicine, Pharmacology and Gastroenterology, New York Medical College, Valhalla, NY, USA.
Jazyk:	angličtina
Zdroj:	Therapeutic advances in chronic disease [Ther Adv Chronic Dis] 2020 Feb 05; Vol. 11, pp. 2040622319894466. Date of Electronic Publication: 2020 Feb 05 (Print Publication: 2020).
DOI:	10.1177/2040622319894466
Abstrakt:	Peripheral arterial disease (PAD) affects individuals particularly over 65 years old in the more advanced countries. Hemodynamic, inflammatory, and oxidative mechanisms interact in the pathophysiological scenario of this chronic arterial disease. We discuss the hemodynamic, muscle tissue, and oxidative stress (OxS) conditions related to chronic ischemia of the peripheral arteries. This review summarizes the results of evaluating both metabolic and oxidative markers, and also therapy to counteract OxS. In conclusion, we believe different pathways should be highlighted to discover new drugs to treat patients suffering from PAD. Competing Interests: Conflict of interest statement: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. (© The Author(s), 2020.)
Databáze:	MEDLINE
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