Postinfectious Bronchiolitis Obliterans in Children: Diagnostic Workup and Therapeutic Options: A Workshop Report.

Autor: Jerkic SP; Division for Allergy, Pneumology and Cystic Fibrosis, Department for Children and Adolescence, Goethe-University, Frankfurt/Main, Germany., Brinkmann F; Department of Paediatric Pneumology, Children's Hospital, Ruhr University of Bochum, Bochum, Germany., Calder A; Radiology Department, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK., Casey A; Boston Children's Hospital, Harvard Medical School, Boston, USA., Dishop M; Division of Pathology and Laboratory Medicine, Phoenix Children's Hospital, Phoenix, USA., Griese M; Department of Pediatric Pneumology, Dr. von Hauner Children's Hospital, LMU Munich, German Center for Lung Research (DZL), Munich, Germany., Kurland G; Division of Pediatric Pulmonary Medicine, Allergy and Immunology, Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, USA., Niemitz M; University of Ulm Medical Centre, Clinic for Child and Adolescent Psychiatry/Psychotherapy, Ulm, Germany., Nyilas S; Division of Respiratory Medicine, Department of Pediatrics, University Children's Hospital of Bern, University of Bern, Bern, Switzerland., Schramm D; Department of General Pediatrics, University Children's Hospital, Düsseldorf, Germany., Schubert R; Division for Allergy, Pneumology and Cystic Fibrosis, Department for Children and Adolescence, Goethe-University, Frankfurt/Main, Germany., Tamm M; Department of Pulmonary Medicine, University Hospital Basel, Basel, Switzerland., Zielen S; Division for Allergy, Pneumology and Cystic Fibrosis, Department for Children and Adolescence, Goethe-University, Frankfurt/Main, Germany., Rosewich M; Division for Allergy, Pneumology and Cystic Fibrosis, Department for Children and Adolescence, Goethe-University, Frankfurt/Main, Germany.
Jazyk: angličtina
Zdroj: Canadian respiratory journal [Can Respir J] 2020 Jan 30; Vol. 2020, pp. 5852827. Date of Electronic Publication: 2020 Jan 30 (Print Publication: 2020).
DOI: 10.1155/2020/5852827
Abstrakt: Bronchiolitis obliterans (BO) is a rare, chronic form of obstructive lung disease, often initiated with injury of the bronchiolar epithelium followed by an inflammatory response and progressive fibrosis of small airways resulting in nonuniform luminal obliteration or narrowing. The term BO comprises a group of diseases with different underlying etiologies, courses, and characteristics. Among the better recognized inciting stimuli leading to BO are airway pathogens such as adenovirus and mycoplasma, which, in a small percentage of infected children, will result in progressive fixed airflow obstruction, an entity referred to as postinfectious bronchiolitis obliterans (PIBO). The present knowledge on BO in general is reasonably well developed, in part because of the relatively high incidence in patients who have undergone lung transplantation or bone marrow transplant recipients who have had graft-versus-host disease in the posttransplant period. The cellular and molecular pathways involved in PIBO, while assumed to be similar, have not been adequately elucidated. Since 2016, an international consortium of experts with an interest in PIBO assembles on a regular basis in Geisenheim, Germany, to discuss key areas in PIBO which include diagnostic workup, treatment strategies, and research fields.
Competing Interests: The authors declare that they have no conflicts of interest.
(Copyright © 2020 Silvija-Pera Jerkic et al.)
Databáze: MEDLINE
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