Effects of dietary and physical activity interventions on generic and cancer-specific health-related quality of life, anxiety, and depression in colorectal cancer survivors: a randomized controlled trial.

Autor: Ho M; School of Nursing, The University of Hong Kong, 4/F William M.W. Mong Block, 21 Sassoon Road, Pok Fu Lam, Hong Kong., Ho JWC; Department of Surgery, The University of Hong Kong, Pok Fu Lam, Hong Kong., Fong DYT; School of Nursing, The University of Hong Kong, 4/F William M.W. Mong Block, 21 Sassoon Road, Pok Fu Lam, Hong Kong. dytfong@hku.hk., Lee CF; Centre for Sports and Exercise, The University of Hong Kong, Pok Fu Lam, Hong Kong., Macfarlane DJ; Centre for Sports and Exercise, The University of Hong Kong, Pok Fu Lam, Hong Kong., Cerin E; School of Public Health, The University of Hong Kong, Pok Fu Lam, Hong Kong.; Mary MacKillop Institute for Health Research, Australia Catholic University, Melbourne, Australia., Lee AM; Department of Psychology, The University of Hong Kong, Pok Fu Lam, Hong Kong., Leung S; School of Nursing, Hong Kong Baptist Hospital, Kowloon Tong, Hong Kong., Chan WYY; School of Professional and Continuing Education, The University of Hong Kong, Pok Fu Lam, Hong Kong., Leung IPF; Department of Dietetics, Queen Elizabeth Hospital, Kowloon, Hong Kong., Lam SHS; Centre for Sports and Exercise, The University of Hong Kong, Pok Fu Lam, Hong Kong., Chu N; Department of Surgery, The University of Hong Kong, Pok Fu Lam, Hong Kong., Taylor AJ; Institute of Applied Health Research, University of Birmingham, Birmingham, UK., Cheng KK; Institute of Applied Health Research, University of Birmingham, Birmingham, UK.
Jazyk: angličtina
Zdroj: Journal of cancer survivorship : research and practice [J Cancer Surviv] 2020 Aug; Vol. 14 (4), pp. 424-433. Date of Electronic Publication: 2020 Feb 18.
DOI: 10.1007/s11764-020-00864-0
Abstrakt: Purpose: To assess the effects of dietary and physical activity (PA) interventions on generic and cancer-specific quality of life (QoL), anxiety, and depression levels among adult Chinese colorectal cancer (CRC) survivors.
Methods: Two-hundred twenty-three adult CRC survivors within 1 year of completion of primary cancer treatment were randomized to receive dietary, PA or combined intervention, or usual care for a 12 monthduration, under a 2 (diet vs usual care) × 2 (PA vs usual care) factorial design. Generic and cancer-specific QoL was assessed using a Chinese version 12-Item Short Form Health Survey (SF-12) and the Functional Assessment of Cancer Therapy-Colorectal (FACT-C) scale, respectively. Anxiety and depression was assessed using the Hospital Anxiety and Depression Scale at baseline, 6, 12, 18, and 24 months. Linear mixed models were used for examining the intervention effects.
Results: Participants receiving dietary intervention experienced a significant improvement in the generic measure of QoL (SF-6D utility scores, mean difference 0.042, 95%CI 0.03 to 0.081) at 12 months, the cancer-specific QoL scores (mean difference 3.09, 95%CI 0.13 to 6.04), and levels of depression (P = 0.015) at both 12 and 24 months follow-up. Participants receiving PA intervention only demonstrated a significant improvement in SF-6D utility index (mean difference 0.039, 95%CI 0.002 to 0.077) and physical functioning (mean difference 2.85, 95%CI 1.00 to 4.70) at 6 months.
Conclusions: Dietary intervention improved the generic and cancer-specific QoL and depression in CRC survivors.
Trial Registration: The study was prospectively registered on 17 October 2012 at ClinicalTrials.gov (NCT01708824).
Implications for Cancer Survivors: CRC survivors can benefit from dietary interventions in alleviating depression and improving overall health-related QoL.
Databáze: MEDLINE
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