Prevalence of Epstein-Barr virus DNA in tonsillar tissue from patients with chronic tonsillitis in Mexican population.
| Autor: | Gonzalez-Lucano LR; Tecnológico de Monterrey, Campus Guadalajara, Zapopan, Jalisco, México. rene.lucano@itesm.mx., Vasquez-Armenta GV; Tecnológico de Monterrey, Campus Guadalajara, Zapopan, Jalisco, México. gaby@itesm.mx., Pereira-Suarez AL; Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Jalisco, México. analauraps@hotmail.com., Ramirez-de Arellano A; Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Jalisco, México. adrian.ramirezdearellano@hotmail.com., Ramirez-de Los Santos S; Centro Universitario de los Altos, Universidad de Guadalajara, Tepatitlán de Morelos, Jalisco, México. saul.ridels@gmail.com., Lopez-Pulido EI; Centro Universitario de los Altos, Universidad de Guadalajara, Tepatitlán de Morelos, Jalisco, México. edgar.lopez@cualtos.udg.mx. |
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| Jazyk: | angličtina |
| Zdroj: | Journal of infection in developing countries [J Infect Dev Ctries] 2019 Aug 31; Vol. 13 (8), pp. 764-767. Date of Electronic Publication: 2019 Aug 31. |
| DOI: | 10.3855/jidc.11424 |
| Abstrakt: | Introduction: Epstein-Barr Virus (EBV) infection prevails in underdeveloped and developing countries. The tonsils seem to be candidate replication sites for EBV and some studies have exposed a close association among viral infections and chronic tonsillitis. The objective of this study was identifying the EBV prevalence in Mexican patients who had undergone tonsillectomy because of chronic tonsillitis. Methodology: Frozen tissues and medical records were obtained from 50 Mexican patients. DNA was extracted and subjected to PCR to amplify the EBER-2 region of EBV. Next, the patients were classified according to general and clinical characteristics searching a relation with the EBV-DNA positivity. Results: EBV genome was detected in 46% (23/50) of the analysed tonsil tissues. Trends were found regarding the relationship of viral presence with lower values in terms of age (6.1 ± 2.8 vs 7.6 ± 3.7) , a greater degree of hypertrophy (3.5 ± 0.4 vs 3.0 ± 0.6) and an increase in the number of episodes of tonsillitis (11 ± 7.4 vs 9 ± 6.5). Conclusions: The prevalence found of EBV-DNA positivity in tonsillar tissues from patients diagnosed with chronic tonsillitis , supports the fact that palatine tonsils can be occupied by EBV and highlights the importance of conducting future studies focused on understanding the role of the EBV infection in chronic inflammatory processes in the population involved in this study. Competing Interests: No Conflict of Interest is declared (Copyright (c) 2019 Edgar Ivan Lopez-Pulido, Luis Renee Gonzalez-Lucano, Luis Renee Gonzalez-Lucano.) |
| Databáze: | MEDLINE |
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