A Toll-receptor map underlies structural brain plasticity.

Autor:	Li G; Neurodevelopment Lab, School of Biosciences, University of Birmingham, Birmingham, United Kingdom.; Rudolf Virchow Center for Experimental Biomedicine, University of Würzburg, Würzburg, Germany., Forero MG; Facultad de Ingeniería, Universidad de Ibagué, Ibagué, Colombia., Wentzell JS; Neurodevelopment Lab, School of Biosciences, University of Birmingham, Birmingham, United Kingdom., Durmus I; Neurodevelopment Lab, School of Biosciences, University of Birmingham, Birmingham, United Kingdom., Wolf R; Rudolf Virchow Center for Experimental Biomedicine, University of Würzburg, Würzburg, Germany., Anthoney NC; Neurodevelopment Lab, School of Biosciences, University of Birmingham, Birmingham, United Kingdom., Parker M; Neurodevelopment Lab, School of Biosciences, University of Birmingham, Birmingham, United Kingdom., Jiang R; Neurodevelopment Lab, School of Biosciences, University of Birmingham, Birmingham, United Kingdom., Hasenauer J; Neurodevelopment Lab, School of Biosciences, University of Birmingham, Birmingham, United Kingdom., Strausfeld NJ; Rudolf Virchow Center for Experimental Biomedicine, University of Würzburg, Würzburg, Germany.; Neuroscience, University of Arizona College of Science, Tucson, United States., Heisenberg M; Rudolf Virchow Center for Experimental Biomedicine, University of Würzburg, Würzburg, Germany., Hidalgo A; Neurodevelopment Lab, School of Biosciences, University of Birmingham, Birmingham, United Kingdom.
Jazyk:	angličtina
Zdroj:	ELife [Elife] 2020 Feb 18; Vol. 9. Date of Electronic Publication: 2020 Feb 18.
DOI:	10.7554/eLife.52743
Abstrakt:	Experience alters brain structure, but the underlying mechanism remained unknown. Structural plasticity reveals that brain function is encoded in generative changes to cells that compete with destructive processes driving neurodegeneration. At an adult critical period, experience increases fiber number and brain size in Drosophila . Here, we asked if Toll receptors are involved. Tolls demarcate a map of brain anatomical domains. Focusing on Toll-2, loss of function caused apoptosis, neurite atrophy and impaired behaviour. Toll-2 gain of function and neuronal activity at the critical period increased cell number. Toll-2 induced cycling of adult progenitor cells via a novel pathway, that antagonized MyD88-dependent quiescence, and engaged Weckle and Yorkie downstream. Constant knock-down of multiple Tolls synergistically reduced brain size. Conditional over-expression of Toll-2 and wek at the adult critical period increased brain size. Through their topographic distribution, Toll receptors regulate neuronal number and brain size, modulating structural plasticity in the adult brain. Competing Interests: GL, MF, JW, ID, RW, NA, MP, RJ, JH, NS, MH, AH No competing interests declared (© 2020, Li et al.)
Databáze:	MEDLINE
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