| Autor: |
Tan FHP; School of Biological Sciences, Universiti Sains Malaysia, 11800 Penang, Malaysia.; USM-RIKEN International Centre for Ageing Science (URICAS), Universiti Sains Malaysia, 11800 Penang, Malaysia., Liu G; CAS Key Laboratory of Microbial Physiological and Metabolic Engineering, State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China P.R., Lau SA; School of Industrial Technology, Universiti Sains Malaysia, 11800 Penang, Malaysia., Jaafar MH; School of Industrial Technology, Universiti Sains Malaysia, 11800 Penang, Malaysia.; USM-RIKEN International Centre for Ageing Science (URICAS), Universiti Sains Malaysia, 11800 Penang, Malaysia., Park YH; Department of Microbiology, Yeungnam University, 38541 Gyeongbuk, Republic of Korea., Azzam G; School of Biological Sciences, Universiti Sains Malaysia, 11800 Penang, Malaysia.; USM-RIKEN International Centre for Ageing Science (URICAS), Universiti Sains Malaysia, 11800 Penang, Malaysia., Li Y; CAS Key Laboratory of Microbial Physiological and Metabolic Engineering, State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China P.R., Liong MT; School of Industrial Technology, Universiti Sains Malaysia, 11800 Penang, Malaysia.; USM-RIKEN International Centre for Ageing Science (URICAS), Universiti Sains Malaysia, 11800 Penang, Malaysia. |
| Abstrakt: |
Alzheimer's disease (AD) is a progressive disease and one of the most common forms of neurodegenerative disorders. Emerging evidence is supporting the use of various strategies that modulate gut microbiota to exert neurological and psychological changes. This includes the utilisation of probiotics as a natural and dietary intervention for brain health. Here, we showed the potential AD-reversal effects of Lactobacillus probiotics through feeding to our Drosophila melanogaster AD model. The administration of Lactobacillus strains was able to rescue the rough eye phenotype (REP) seen in AD-induced Drosophila , with a more prominent effect observed upon the administration of Lactobacillus plantarum DR7 (DR7). Furthermore, we analysed the gut microbiota of the AD-induced Drosophila and found elevated levels of Wolbachia . The administration of DR7 restored the gut microbiota diversity of AD-induced Drosophila with a significant reduction in Wolbachia 's relative abundance, accompanied by an increase of Stenotrophomonas and Acetobacter . Through functional predictive analyses, Wolbachia was predicted to be positively correlated with neurodegenerative disorders, such as Parkinson's, Huntington's and Alzheimer's diseases, while Stenotrophomonas was negatively correlated with these neurodegenerative disorders. Altogether, our data exhibited DR7's ability to ameliorate the AD effects in our AD-induced Drosophila . Thus, we propose that Wolbachia be used as a potential biomarker for AD. |
