| Autor: |
You YY; Department of Epidemiology and Statistics, School of Public Health, Jilin University, Changchun 130021, China; Health Education Division, Center for Chronic Disease Control, Nanshan District, Shenzhen 518000, China., Song Y; Department of Epidemiology and Statistics, School of Public Health, Jilin University, Changchun 130021, China., Wang MH; Department of Epidemiology and Statistics, School of Public Health, Jilin University, Changchun 130021, China., Zhang LL; Department of Epidemiology and Statistics, School of Public Health, Jilin University, Changchun 130021, China., Bai W; Department of Epidemiology and Statistics, School of Public Health, Jilin University, Changchun 130021, China., Yu WY; Department of Epidemiology and Statistics, School of Public Health, Jilin University, Changchun 130021, China., Yu YQ; Department of Epidemiology and Statistics, School of Public Health, Jilin University, Changchun 130021, China., Kou CG; Department of Epidemiology and Statistics, School of Public Health, Jilin University, Changchun 130021, China. |
| Abstrakt: |
Objective: To investigate the relationship between exposure to famine in fetus and infant period and the risks for hypertension in adulthood. Methods: A total of 5 960 participants born between 1956 and 1965 were included in the study and were divided into unexposed group (1963-1965), fetal exposed group (1959-1961), early- childhood exposed group (1956-1958) and transitional group (1962). Logistic regression model was used to explore the association between famine exposure in early life and the risk for hypertension in adulthood. Results: Both the fetal exposure and the early-childhood exposure were the risk factors for hypertension in adulthood ( OR =1.249, 95 %CI : 1.049-1.486 and OR =1.360, 95 %CI : 1.102-1.679). Meanwhile, in rural area, compared with unexposed group, the fetal exposure ( OR =1.401, 95 %CI : 1.091-1.798) and the early-childhood exposure ( OR =1.460, 95 %CI : 1.145-1.862) were also associated with a greater risk of hypertension in adulthood. In addition, fetal exposure and early-childhood exposure to famine in women were associated with 36.0 % and 31.9 % increased risks for hypertension (95 %CI : 7.8 % -71.7 % and 95 %CI : 4.8 % -66.0 % ) according to the stratified analysis. Conclusion: Fetal exposure to famine might increase the risk for hypertension in adulthood. |
