Baroreflex function and postprandial hypotension in older adults.

Autor: Madden KM; Gerontology and Diabetes Research Laboratory, Division of Geriatric Medicine, Department of Medicine, University of British Columbia, Vancouver, BC, Canada. Kenneth.Madden@vch.ca.; Centre for Hip Health and Mobility, University of British Columbia, Vancouver, BC, Canada. Kenneth.Madden@vch.ca.; Allan M. McGavin Chair in Geriatric Medicine, Room 7185, Gordon and Leslie Diamond Health Care Centre, 2775 Laurel St., Vancouver, BC, V5Z 1M9, Canada. Kenneth.Madden@vch.ca., Feldman B; Gerontology and Diabetes Research Laboratory, Division of Geriatric Medicine, Department of Medicine, University of British Columbia, Vancouver, BC, Canada., Meneilly GS; Gerontology and Diabetes Research Laboratory, Division of Geriatric Medicine, Department of Medicine, University of British Columbia, Vancouver, BC, Canada.
Jazyk: angličtina
Zdroj: Clinical autonomic research : official journal of the Clinical Autonomic Research Society [Clin Auton Res] 2021 Apr; Vol. 31 (2), pp. 273-280. Date of Electronic Publication: 2020 Feb 15.
DOI: 10.1007/s10286-020-00671-8
Abstrakt: Purpose: Postprandial hypotension (PPH) is a common but poorly understood etiology for fainting in older adults. One potential mechanism is age-related baroreflex dysfunction. We examined baroreflex function in older adults with PPH and without PPH (noPPH) during a standardized meal test.
Methods: 57 adults (age ≥ 65; 24 PPH, 33 noPPH, mean age 77.9 ± 0.9 years, 54% female) were recruited and had meal tests performed. The baroreflex effectiveness index (BEI, %) and baroreflex sensitivity (BRS, ms/mm Hg) were calculated using the sequence method.
Results: Baseline BEI (22 ± 2 versus 23 ± 2 percent, t = - 0.411, p = 0.682) and BRS (14.1 ± 2.4 versus 13.8 ± 2.5 ms/mm of Hg, t = - 0.084, p = 0.933) were similar in PPH and noPPH subjects. During the meal test PPH subjects showed significantly lower BEI as compared to noPPH subjects (time × PPH, F = 2.791, p = 0.042), while there was no difference in the postprandial change in BRS (time, F = 0.618, p = 0.605).
Conclusion: Patients with PPH demonstrated an acute postprandial decrease in baroreflex effectiveness during meal testing as compared with normal subjects, suggesting a potential contributing mechanism for this condition.
Databáze: MEDLINE
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