Reproducible research practices, openness and transparency in health economic evaluations: study protocol for a cross-sectional comparative analysis.

Autor:	Catalá-López F; Department of Health Planning and Economics, National School of Public Health, Institute of Health Carlos III, Madrid, Spain ferran_catala@outlook.com.; Department of Medicine, University of Valencia/INCLIVA Health Research Institute and CIBERSAM, Valencia, Spain.; Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada., Caulley L; Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.; Otolaryngology-Head and Neck Surgery Department, Ottawa Hospital, Ottawa, Ontario, Canada.; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.; Ear, Nose and Throat Department, Guy's Hospital, London, UK., Ridao M; Instituto Aragonés de Ciencias de la Salud (IACS), Red de Investigación en Servicios de Salud en Enfermedades Crónicas (REDISSEC), Zaragoza, Spain., Hutton B; Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.; School of Epidemiology and Public Health, University of Ottawa, Ottawa, Ontario, Canada., Husereau D; Institute of Health Economics, Edmonton, Alberta, Canada.; Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada., Drummond MF; Centre for Health Economics, University of York, York, UK., Alonso-Arroyo A; Department of History of Science and Documentation, University of Valencia, Valencia, Spain.; Information and Social and Health Research Unit (UISYS), University of Valencia and Spanish National Research Council (CSIC), Valencia, Spain., Pardo-Fernández M; Spanish Medicines and Healthcare Products Agency (AEMPS), Madrid, Spain., Bernal-Delgado E; Instituto Aragonés de Ciencias de la Salud (IACS), Red de Investigación en Servicios de Salud en Enfermedades Crónicas (REDISSEC), Zaragoza, Spain., Meneu R; Fundación Instituto de Investigación en Servicios de Salud, Valencia, Spain., Tabarés-Seisdedos R; Department of Medicine, University of Valencia/INCLIVA Health Research Institute and CIBERSAM, Valencia, Spain., Repullo JR; Department of Health Planning and Economics, National School of Public Health, Institute of Health Carlos III, Madrid, Spain., Moher D; Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.; School of Epidemiology and Public Health, University of Ottawa, Ottawa, Ontario, Canada.
Jazyk:	angličtina
Zdroj:	BMJ open [BMJ Open] 2020 Feb 13; Vol. 10 (2), pp. e034463. Date of Electronic Publication: 2020 Feb 13.
DOI:	10.1136/bmjopen-2019-034463
Abstrakt:	Introduction: There has been a growing awareness of the need for rigorously and transparent reported health research, to ensure the reproducibility of studies by future researchers. Health economic evaluations, the comparative analysis of alternative interventions in terms of their costs and consequences, have been promoted as an important tool to inform decision-making. The objective of this study will be to investigate the extent to which articles of economic evaluations of healthcare interventions indexed in MEDLINE incorporate research practices that promote transparency, openness and reproducibility. Methods and Analysis: This is the study protocol for a cross-sectional comparative analysis. We registered the study protocol within the Open Science Framework (osf.io/gzaxr). We will evaluate a random sample of 600 cost-effectiveness analysis publications, a specific form of health economic evaluations, indexed in MEDLINE during 2012 (n=200), 2019 (n=200) and 2022 (n=200). We will include published papers written in English reporting an incremental cost-effectiveness ratio in terms of costs per life years gained, quality-adjusted life years and/or disability-adjusted life years. Screening and selection of articles will be conducted by at least two researchers. Reproducible research practices, openness and transparency in each article will be extracted using a standardised data extraction form by multiple researchers, with a 33% random sample (n=200) extracted in duplicate. Information on general, methodological and reproducibility items will be reported, stratified by year, citation of the Consolidated Health Economic Evaluation Reporting Standards (CHEERS) statement and journal. Risk ratios with 95% CIs will be calculated to represent changes in reporting between 2012-2019 and 2019-2022. Ethics and Dissemination: Due to the nature of the proposed study, no ethical approval will be required. All data will be deposited in a cross-disciplinary public repository. It is anticipated the study findings could be relevant to a variety of audiences. Study findings will be disseminated at scientific conferences and published in peer-reviewed journals. Competing Interests: Competing interests: None declared. (© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.)
Databáze:	MEDLINE
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