Rhythm disturbances as a potential early marker of Parkinson's disease in idiopathic REM sleep behavior disorder.

Autor: Cochen De Cock V; Sleep and Neurology Department, Beau Soleil Clinic, Montpellier, France.; Clinical Investigation Centre (CIC) 1411, University Hospital of Montpellier & Inserm, Montpellier, France.; EuroMov, Université de Montpellier, Montpellier, France., de Verbizier D; Nuclear Medicine Unit, University Hospital of Montpellier, Montpellier, France., Picot MC; Clinical Investigation Centre (CIC) 1411, University Hospital of Montpellier & Inserm, Montpellier, France.; Clinical Research & Epidemiology Unit, Medical Information Department, CHU Montpellier, University of Montpellier, Montpellier, France., Damm L; EuroMov, Université de Montpellier, Montpellier, France., Abril B; Sleep Department, University Hospital of Nîmes, Nîmes, France., Galtier F; Clinical Investigation Centre (CIC) 1411, University Hospital of Montpellier & Inserm, Montpellier, France., Driss V; Clinical Investigation Centre (CIC) 1411, University Hospital of Montpellier & Inserm, Montpellier, France., Lebrun C; Clinical Investigation Centre (CIC) 1411, University Hospital of Montpellier & Inserm, Montpellier, France., Pageot N; Department of Neurology, University Hospital of Montpellier, Montpellier, France., Giordano A; Clinical Investigation Centre (CIC) 1411, University Hospital of Montpellier & Inserm, Montpellier, France., Gonzalvez C; Clinical Investigation Centre (CIC) 1411, University Hospital of Montpellier & Inserm, Montpellier, France., Homeyer P; Sleep Department, Aubenas Hospital, Aubenas, France., Carlander B; Department of Neurology, University Hospital of Montpellier, Montpellier, France., Castelnovo G; Department of Neurology, University Hospital of Nîmes, Nîmes, France., Geny C; EuroMov, Université de Montpellier, Montpellier, France.; Department of Neurology, University Hospital of Montpellier, Montpellier, France., Bardy B; EuroMov, Université de Montpellier, Montpellier, France.; Institut Universitaire de France (IUF), Paris, France., Dalla Bella S; EuroMov, Université de Montpellier, Montpellier, France.; International Laboratory for Brain, Music, and Sound Research (BRAMS), Montreal, Canada.; Department of Psychology, University of Montreal, Montreal, Canada.; Department of Cognitive Psychology, University of Economics and Human Sciences in Warsaw, Warsaw, Poland.
Jazyk: angličtina
Zdroj: Annals of clinical and translational neurology [Ann Clin Transl Neurol] 2020 Mar; Vol. 7 (3), pp. 280-287. Date of Electronic Publication: 2020 Feb 14.
DOI: 10.1002/acn3.50982
Abstrakt: Objective: We aimed to identify timing distortions in production and perception of rhythmic events in patients with idiopathic REM sleep behavior disorder (iRBD) as early markers of Parkinson's disease (PD).
Methods: Rhythmic skills, clinical characteristics, dysautonomia, depression, and olfaction were compared in 97 participants, including 21 participants with iRBD, 38 patients with PD, and 38 controls, matched for age, gender, and education level. Rhythmic disturbances can be easily detected with dedicated motor tasks via a tablet application. Rhythm production was tested in two conditions: to examine the ability to generate a spontaneous endogenous rhythm, tapping rate and variability in a finger tapping task without external stimulation was measured, while the ability to synchronize to an external rhythm was tested with finger tapping to external auditory cues. Rhythm perception was measured with a task, in which the participants had to detect a deviation from a regular rhythm. Participants with iRBD had dopamine transporter imaging.
Results: Participants with iRBD and PD revealed impaired spontaneous rhythm production and poor rhythm perception compared to controls. Impaired rhythm production was correlated with olfaction deficits, dysautonomia, impaired non-motor aspects of daily living, and dopamine uptake measures.
Conclusions: Participants with iRBD show impaired rhythm production and perception; this impairment is correlated with other early markers for PD. Testing rhythmic skills with short and inexpensive tests may be promising for screening for potential future PD in iRBD patients.
(© 2020 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals, Inc on behalf of American Neurological Association.)
Databáze: MEDLINE
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