Management of multidrug-resistant tuberculosis with shorter treatment regimen in Niger: Nationwide programmatic achievements.

Autor: Piubello A; Damien Foundation, Niamey, Niger; International Union Against Tuberculosis and Lung Disease, Paris, France. Electronic address: apiubello@theunion.org., Souleymane MB; Damien Foundation, Niamey, Niger., Hassane-Harouna S; Damien Foundation, Niamey, Niger., Yacouba A; Regional Hospital Agadez, Niger., Lempens P; Unit of Mycobacteriology, Department of Biomedical Sciences, Institute of Tropical Medicine, Antwerp, Belgium., Assao-Neino MM; National Tuberculosis Programme, Niamey, Niger., Maman-Lawan I; Damien Foundation, Niamey, Niger., Attaher S; Regional Hospital, Maradi, Niger., Moustapha B; National Tuberculosis Programme, Niamey, Niger., Soumana A; National Anti-Tuberculosis Centre, Niamey, Niger., Gagara-Issoufou A; University Hospital Lamorde, Niamey, Niger., Ortuño-Gutiérrez N; Damien Foundation, Brussels, Belgium., Roggi A; Damien Foundation, Brussels, Belgium., Gumusboga M; Unit of Mycobacteriology, Department of Biomedical Sciences, Institute of Tropical Medicine, Antwerp, Belgium., Hamidou-Harouna Z; National Reference Laboratory of Tuberculosis, Niamey, Niger., Dockx J; Unit of Mycobacteriology, Department of Biomedical Sciences, Institute of Tropical Medicine, Antwerp, Belgium., Mamadou S; Abdou Moumouni University, Niamey, Niger., de Jong BC; Unit of Mycobacteriology, Department of Biomedical Sciences, Institute of Tropical Medicine, Antwerp, Belgium., Decroo T; Unit of HIV & Co-infections, Department of Clinical Sciences, Institute of Tropical Medicine, Antwerp, Belgium; Research Foundation Flanders, Brussels, Belgium., Van Deun A; International Union Against Tuberculosis and Lung Disease, Paris, France; Regional Hospital Agadez, Niger; Unit of Mycobacteriology, Department of Biomedical Sciences, Institute of Tropical Medicine, Antwerp, Belgium.
Jazyk: angličtina
Zdroj: Respiratory medicine [Respir Med] 2020 Jan; Vol. 161, pp. 105844. Date of Electronic Publication: 2019 Nov 23.
DOI: 10.1016/j.rmed.2019.105844
Abstrakt: Background: In Niger, the Shorter Treatment Regimen (STR) has been implemented nationwide for rifampicin resistant tuberculosis (RR-TB), since 2008. No previous publication has shown the results from countrywide programmatic implementation using few exclusion criteria, nor exhaustively assessed the effect of initial resistance to companion drugs on outcomes.
Methods: The National Tuberculosis Programme and the Damien Foundation conducted a retrospective observational study to evaluate the management of RR-TB from 2008 to 2016. Baseline resistance to drugs was assessed phenotypically, complemented by screening the inhA, katG and pncA genes. Cured patients were followed-up for a period of one year after cure.
Findings: Among 1044 patients tested for rifampicin resistance, mainly previously treated patients, 332 were diagnosed with pulmonary RR/TB, 288 were enrolled on treatment and 255 started on STR. Six patients received a modified STR. Among 249 patients on standardised STR, 207 (83·1%) were cured relapse-free, eight (3·2%) had failure, 23 (9·2%) died, seven (2·8%) were lost to follow-up and four (1·6%) relapsed. The risk of unfavourable outcome was higher in patients with initial resistance to fluoroquinolones (aOR 20·4, 95%CI:5·6-74·6) and very severely underweight (aOR 3·9, 95%CI:1·5-10·1). Successful outcome was not affected by initial resistance to companion drugs. Serious ototoxicity was reported in eight patients (3·2%).
Interpretation: A comprehensive nationwide approach to multidrug-resistant tuberculosis management using the STR was feasible and successful. Outcomes were not affected by initial resistance to companion drugs. Our study confirms the effectiveness and safety of the STR.
Funding: Damien Foundation and Institute of Tropical Medicine-Antwerp.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2019 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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