Expression of fucosylated glycans in endothelial glycocalyces of placental villi at early and late fetal growth restriction.

Autor: Ziganshina MM; National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I. Kulakov of the Ministry of Health of Russian Federation, Moscow, Russia. Electronic address: mmz@mail.ru., Kulikova GV; National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I. Kulakov of the Ministry of Health of Russian Federation, Moscow, Russia., Fayzullina NM; National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I. Kulakov of the Ministry of Health of Russian Federation, Moscow, Russia., Yarotskaya EL; National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I. Kulakov of the Ministry of Health of Russian Federation, Moscow, Russia., Shchegolev AI; National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I. Kulakov of the Ministry of Health of Russian Federation, Moscow, Russia., Le Pendu J; CRCINA, Inserm, Université d'Angers, Université de Nantes, Nantes, France., Breiman A; CRCINA, Inserm, Université d'Angers, Université de Nantes, Nantes, France; CHU Nantes, Nantes, France., Shilova NV; National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I. Kulakov of the Ministry of Health of Russian Federation, Moscow, Russia; The M.M. Shemyakin-Yu.A. Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Science, Moscow, Russia., Khasbiullina NR; National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I. Kulakov of the Ministry of Health of Russian Federation, Moscow, Russia; The N.D. Zelinsky Institute of Organic Chemistry of the Russian Academy of Science, Moscow, Russia., Bovin NV; The M.M. Shemyakin-Yu.A. Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Science, Moscow, Russia., Kan NE; National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I. Kulakov of the Ministry of Health of Russian Federation, Moscow, Russia., Tyutyunnik VL; National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I. Kulakov of the Ministry of Health of Russian Federation, Moscow, Russia., Khodzhaeva ZS; National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I. Kulakov of the Ministry of Health of Russian Federation, Moscow, Russia., Sukhikh GT; National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I. Kulakov of the Ministry of Health of Russian Federation, Moscow, Russia; Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov First Mossow State Medical University under the Ministry of Health of the Russian Federation (Sechenov University), Moscow, Russia.
Jazyk: angličtina
Zdroj: Placenta [Placenta] 2020 Jan 15; Vol. 90, pp. 98-102. Date of Electronic Publication: 2019 Dec 11.
DOI: 10.1016/j.placenta.2019.12.005
Abstrakt: The aim of the study was to investigate the content and distribution of fucosylated sugar residues and Lewis Y (Le Y ) in the endothelial glycocalyx (eGC) in placental tissue at early and late onset fetal growth restriction (FGR). Our findings demonstrated that the changes of the fucosylated glycans of type 2 (H2)/Le Y in the vascular endothelium of the villi may reflect alteration of villi maturation, or adaptation to hypoxia through the change of cell proliferation potential and induction angiogenesis. Early onset FGR differs from late onset FGR by a markedly increased Le Y expression, being associated with more severe pathological state.
Competing Interests: Declaration of competing interest The authors report no conflicts of interest.
(Copyright © 2019 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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