Miro: A molecular switch at the center of mitochondrial regulation.

Autor: Eberhardt EL; Life Sciences Institute, Department of Biological Chemistry, University of Michigan, Ann Arbor, Michigan.; Cellular and Molecular Biology Program, University of Michigan, Ann Arbor, Michigan., Ludlam AV; Life Sciences Institute, Department of Biological Chemistry, University of Michigan, Ann Arbor, Michigan., Tan Z; Life Sciences Institute, Department of Biological Chemistry, University of Michigan, Ann Arbor, Michigan.; Biophysics Program, University of Michigan, Ann Arbor, Michigan., Cianfrocco MA; Life Sciences Institute, Department of Biological Chemistry, University of Michigan, Ann Arbor, Michigan.
Jazyk: angličtina
Zdroj: Protein science : a publication of the Protein Society [Protein Sci] 2020 Jun; Vol. 29 (6), pp. 1269-1284. Date of Electronic Publication: 2020 Feb 24.
DOI: 10.1002/pro.3839
Abstrakt: The orchestration of mitochondria within the cell represents a critical aspect of cell biology. At the center of this process is the outer mitochondrial membrane protein, Miro. Miro coordinates diverse cellular processes by regulating connections between organelles and the cytoskeleton that range from mediating contacts between the endoplasmic reticulum and mitochondria to the regulation of both actin and microtubule motor proteins. Recently, a number of cell biological, biochemical, and protein structure studies have helped to characterize the myriad roles played by Miro. In addition to answering questions regarding Miro's function, these studies have opened the door to new avenues in the study of Miro in the cell. This review will focus on summarizing recent findings for Miro's structure, function, and activity while highlighting key questions that remain unanswered.
(© 2020 The Protein Society.)
Databáze: MEDLINE
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