Is Low-Grade Intraventricular Hemorrhage in Very Preterm Infants an Innocent Condition? Structural and Functional Evaluation of the Brain Reveals Regional Neurodevelopmental Abnormalities.

Autor:	Argyropoulou MI; From the Departments of Radiology (M.I.A., V.G.X., V.M., I.G.) margyrop@uoi.gr., Astrakas LG; Medical Physics (L.G.A.)., Xydis VG; From the Departments of Radiology (M.I.A., V.G.X., V.M., I.G.)., Drougia A; Neonatology Unit (A.D., V.G., S.A.), Faculty of Medicine, University of Ioannina, Ioannina, Greece., Mouka V; From the Departments of Radiology (M.I.A., V.G.X., V.M., I.G.)., Goel I; From the Departments of Radiology (M.I.A., V.G.X., V.M., I.G.)., Giapros V; Neonatology Unit (A.D., V.G., S.A.), Faculty of Medicine, University of Ioannina, Ioannina, Greece., Andronikou S; Neonatology Unit (A.D., V.G., S.A.), Faculty of Medicine, University of Ioannina, Ioannina, Greece.
Jazyk:	angličtina
Zdroj:	AJNR. American journal of neuroradiology [AJNR Am J Neuroradiol] 2020 Mar; Vol. 41 (3), pp. 542-547. Date of Electronic Publication: 2020 Feb 13.
DOI:	10.3174/ajnr.A6438
Abstrakt:	Background and Purpose: There is increasing evidence of abnormal neurodevelopmental outcomes in very preterm infants with low-grade intraventricular hemorrhage grades I and II. Our purpose was to evaluate the effects of low-grade intraventricular hemorrhage on gray and white matter integrity. Materials and Methods: MR imaging at around term-equivalent age was performed in 16 very preterm infants (mean gestational age, 28.8 ± 5.3 weeks) with mild intraventricular hemorrhage on brain sonography and 13 control subjects (mean gestational age, 29.6 ± 4.1 weeks) without intraventricular hemorrhage. Structural and functional evaluation of the cortex was performed using regional measurements of surface area, thickness and volume, and resting-state fMRI, respectively, and of WM microstructural integrity, applying Tract-Based Spatial Statistics to diffusion tensor imaging data. Results: Compared with the control infants, the infants with low-grade intraventricular hemorrhage had decreases in the following: 1) GM surface area in Brodmann areas 19 left and 9 and 45 right, and GM volume in Brodmann areas 9 and 10 right; 2) fractional anisotropy bilaterally in major WM tracts; and 3) brain activity in the left lower lateral and in the right higher medial somatosensory cortex. Conclusions: Very premature infants with low-grade intraventricular hemorrhage at around term-equivalent age may present with regional abnormalities, appearing on imaging studies as cortical underdevelopment, functional impairment, and microstructural immaturity of major WM tracts. (© 2020 by American Journal of Neuroradiology.)
Databáze:	MEDLINE
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