Reducing the Toxicity of Radiotherapy for Pancreatic Cancer With Magnetic Resonance-guided Radiotherapy.

Autor:	Tchelebi LT; Department of Radiation Oncology, Penn State Cancer Institute., Zaorsky NG; Department of Radiation Oncology, Penn State Cancer Institute.; Department of Public Health Sciences, Penn State College of Medicine, Hershey, Pennsylvania 17033., Rosenberg JC; Department of Radiation Oncology, Penn State Cancer Institute., Sharma NK; Department of Radiation Oncology, Penn State Cancer Institute., Tuanquin LC; Department of Radiation Oncology, Penn State Cancer Institute., Mackley HB; Department of Radiation Oncology, Penn State Cancer Institute., Ellis RJ; Department of Radiation Oncology, Penn State Cancer Institute.
Jazyk:	angličtina
Zdroj:	Toxicological sciences : an official journal of the Society of Toxicology [Toxicol Sci] 2020 May 01; Vol. 175 (1), pp. 19-23.
DOI:	10.1093/toxsci/kfaa021
Abstrakt:	Pancreatic cancer is a highly fatal malignancy for which surgery is currently considered to be the only curative treatment. However, less than a quarter of patients have disease amenable to definitive surgical resection. Local treatment with radiation therapy is a promising alternative to surgery for those patients with unresectable disease. However, conventional radiation techniques with computed tomography (CT)-guided therapy have yielded disappointing results due to the inability to deliver ablative doses of ionizing radiation, while sparing the radiosensitive adjacent organs at risk. Magnetic resonance-guided radiotherapy (MRgRT) has emerged as an alternative to CT-guided radiation treatment which allows for the delivery of higher doses of radiation with low toxicity to surrounding structures. Further study into the use of MRgRT and dose escalation for locally advanced unresectable pancreatic cancer is needed. (© The Author(s) 2020. Published by Oxford University Press on behalf of the Society of Toxicology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)
Databáze:	MEDLINE
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