Heredity of type 2 diabetes confers increased susceptibility to oxidative stress and inflammation.
| Autor: | Baig S; Medicine, National University of Singapore, Singapore., Shabeer M; Medicine, National University of Singapore, Singapore., Parvaresh Rizi E; Medicine, National University of Singapore, Singapore., Agarwal M; Medicine, National University of Singapore, Singapore.; Department of Pharmacology and Nutritional Sciences, University of Kentucky College of Medicine, Lexington, Kentucky, USA., Lee MH; Medicine, National University of Singapore, Singapore., Ooi DSQ; Department of Paediatrics, National University of Singapore, Singapore.; Khoo Teck Puat-National University Children's Medical Institute, National University Health System, Singapore., Chia C; Medicine, National University Health System, Singapore.; School of Medicine, Trinity College Dublin, Dublin, Ireland., Aung N; Medicine, National University of Singapore, Singapore., Ng G; Medicine, National University of Singapore, Singapore., Teo Y; Medicine, National University of Singapore, Singapore., Chhay V; Medicine, National University of Singapore, Singapore., Magkos F; Section for Obesity Research, Department of Nutrition, Exercise and Sports, University of Copenhagen, København, Denmark., Vidal-Puig A; Department of Clinical Biochemistry, University of Cambridge School of Clinical Medicine, Cambridge, Cambridgeshire, UK., Seet RCS; Medicine, National University of Singapore, Singapore.; Medicine, National University Health System, Singapore., Toh SA; Medicine, National University of Singapore, Singapore mdcsates@nus.edu.sg.; Department of Endocrinology, Diabetes and Metabolism, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA. |
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| Jazyk: | angličtina |
| Zdroj: | BMJ open diabetes research & care [BMJ Open Diabetes Res Care] 2020 Jan; Vol. 8 (1). |
| DOI: | 10.1136/bmjdrc-2019-000945 |
| Abstrakt: | Introduction and Objective: Heredity of type 2 diabetes mellitus (T2DM) is associated with greater risk for developing T2DM. Thus, individuals who have a first-degree relative with T2DM (FDRT) provide a natural model to study factors of susceptibility towards development of T2DM, which are poorly understood. Emerging key players in T2DM pathophysiology such as adverse oxidative stress and inflammatory responses could be among possible mechanisms that predispose FDRTs to develop T2DM. Here, we aimed to examine the role of oxidative stress and inflammatory responses as mediators of this excess risk by studying dynamic postprandial responses in FDRTs. Research Design and Methods: In this open-label case-control study, we recruited normoglycemic men with (n=9) or without (n=9) a family history of T2DM. We assessed plasma glucose, insulin, lipid profile, cytokines and F Results: Postprandial glucose and insulin responses were not different between groups. Expression of oxidant transcription factor NRF2 protein (p<0.05 for myotubes) and gene (p Conclusions: Our findings shed light on how heredity of T2DM confers increased susceptibility to oxidative stress and inflammation. This could provide early insights into the underlying mechanisms and future risk of FDRTs for developing T2DM and its associated complications. Competing Interests: Competing interests: None declared. (© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.) |
| Databáze: | MEDLINE |
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