| Autor: |
Benvenuto D; Unit of Medical Statistics and Molecular Epidemiology, University Campus Bio-Medico of Rome, Italy., Giovanetti M; Laboratório de Flavivírus, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil., Salemi M; Department of Epidemiology, University of Florida, Gainesville, FL, USA.; Emerging Pathogens Institute, University of Florida, Gainesville, FL, USA., Prosperi M; Department of Epidemiology, University of Florida, Gainesville, FL, USA.; Emerging Pathogens Institute, University of Florida, Gainesville, FL, USA., De Flora C; Unit of Medical Statistics and Molecular Epidemiology, University Campus Bio-Medico of Rome, Italy., Junior Alcantara LC; Laboratório de Flavivírus, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil., Angeletti S; Unit of Clinical Laboratory Science, University Campus Bio-Medico of Rome, Italy., Ciccozzi M; Laboratório de Flavivírus, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil. |
| Abstrakt: |
The global spread of the 2019-nCoV is continuing and is fast moving, as indicated by the WHO raising the risk assessment to high. In this article, we provide a preliminary phylodynamic and phylogeographic analysis of this new virus. A Maximum Clade Credibility tree has been built using the 29 available whole genome sequences of 2019-nCoV and two whole genome sequences that are highly similar sequences from Bat SARS-like Coronavirus available in GeneBank. We are able to clarify the mechanism of transmission among the countries which have provided the 2019-nCoV sequence isolates from their patients. The Bayesian phylogeographic reconstruction shows that the 2019-2020 nCoV most probably originated from the Bat SARS-like Coronavirus circulating in the Rhinolophus bat family. In agreement with epidemiological observations, the most likely geographic origin of the new outbreak was the city of Wuhan, China, where 2019-nCoV time of the most recent common ancestor emerged, according to molecular clock analysis, around November 25 th , 2019. These results, together with previously recorded epidemics, suggest a recurring pattern of periodical epizootic outbreaks due to Betacoronavirus . Moreover, our study describes the same population genetic dynamic underlying the SARS 2003 epidemic, and suggests the urgent need for the development of effective molecular surveillance strategies of Betacoronavirus among animals and Rhinolophus of the bat family. |
