Questionnaire-guided evaluation of the effectiveness of long-term intravesical 0.2% chondroitin sulfate therapy in interstitial cystitis.

Autor: Kocatürk H; Department of Urology Health Sciences University, Erzurum Regional Training and Research Hospital, 25070, Palandöken/Erzurum, Turkey. kocaturk78@hotmail.com., Atasoy N; Department of Urology Health Sciences University, Erzurum Regional Training and Research Hospital, 25070, Palandöken/Erzurum, Turkey., Bedir F; Department of Urology Health Sciences University, Erzurum Regional Training and Research Hospital, 25070, Palandöken/Erzurum, Turkey., Altay MS; Department of Urology Health Sciences University, Erzurum Regional Training and Research Hospital, 25070, Palandöken/Erzurum, Turkey., Demirdöğen ŞO; Department of Urology Health Sciences University, Erzurum Regional Training and Research Hospital, 25070, Palandöken/Erzurum, Turkey., Koç E; Department of Urology, Ankara Yıldırım Beyazit University Faculty of Medicine, Ankara Atatürk Training and Research Hospital, Ankara, Turkey., Yilmaz S; Department of Public Health, Atatürk University Faculty of Medicine, Erzurum, Turkey.
Jazyk: angličtina
Zdroj: International urogynecology journal [Int Urogynecol J] 2021 May; Vol. 32 (5), pp. 1293-1298. Date of Electronic Publication: 2020 Feb 11.
DOI: 10.1007/s00192-020-04245-0
Abstrakt: Introduction and Hypothesis: To investigate the long-term feasibility, safety and effectiveness of intravesical chondroitin sulfate therapy in patients with one or more forms of chronic cystitis.
Methods: The study included 62 female patients with interstitial cystitis/painful bladder syndrome (IC/PBS) who received intravesical chondroitin sulfate (40 ml/80 mg) therapy between 2014 and 2018. A total of 15 doses of intravesical treatment were applied, once weekly in the first month and once monthly from the second month onward. A 3-day voiding diary, a visual analog scale (VAS), the O'Leary Sant Indexes (ICSI/ICPI), the Pelvic Pain and Urgency/Frequency Symptom (PPUFS) Scale and PPUF Bother scores were recorded and evaluated through prospective comparison before treatment and at the first month and first year. Patients were also assessed using the Global Response Assessment (GRA) at the end of the first month and first year to assess the effectiveness of responses to treatment.
Results: In the first month of treatment, 0.2% chondroitin sulfate was ineffective in 22.5% of patients, with mild improvement observed in 40.0% and moderate-good improvement in 37.0%. Evaluation at the end of the first year revealed mild improvement in 21.0% of patients and moderate-good improvement in 79.0%. Statistically significant improvements were observed in all scoring systems at 1 and 12 months compared with pre-treatment values (p < 0.001).
Conclusion: Long-term intravesical chondroitin sulfate therapy is a safe and highly successful therapeutic modality that produces significant improvement in patients' quality of life and symptoms in the treatment of IC/PBS.
Databáze: MEDLINE
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