Association Between Neonatal Seizures and Social-Emotional Development and Adaptive Behavior in Extremely Low Birth Weight Infants.

Autor:	Courchia B; Department of Pediatrics, Division of Neonatology, University of Miami Miller School of Medicine, Holtz Children's Hospital, FL, USA.; Mailman Center for Child Development, Miami, FL, USA., Berkovits MD; Department of Pediatrics, Division of Neonatology, University of Miami Miller School of Medicine, Holtz Children's Hospital, FL, USA.; Mailman Center for Child Development, Miami, FL, USA., Kurtom W; Department of Pediatrics, Division of Neonatology, University of Miami Miller School of Medicine, Holtz Children's Hospital, FL, USA., Moral TD; Department of Pediatrics, Division of Neonatology, University of Miami Miller School of Medicine, Holtz Children's Hospital, FL, USA., Bauer CR; Department of Pediatrics, Division of Neonatology, University of Miami Miller School of Medicine, Holtz Children's Hospital, FL, USA.; Mailman Center for Child Development, Miami, FL, USA.
Jazyk:	angličtina
Zdroj:	Journal of child neurology [J Child Neurol] 2020 Apr; Vol. 35 (5), pp. 331-335. Date of Electronic Publication: 2020 Feb 11.
DOI:	10.1177/0883073819901233
Abstrakt:	Aim: To evaluate social-emotional development and adaptive behavioral outcomes in a cohort of extremely low birth weight infants with a confirmed diagnosis of neonatal seizures. Methods: This is a retrospective cohort study of preterm infants weighing ≤1000 g at birth, with a diagnosis of neonatal seizures, evaluated between 21 and 31 months of age using the Bayley Scales of Infant Development (Bayley-III) in a longitudinal neurodevelopmental follow-up program. Seizures were diagnosed using continuous video electroencephalography interpreted by a pediatric neurologist. Results: Nineteen infants meeting criteria were included and were matched with 38 control subjects, without clinical signs of seizures, and similar baseline characteristics. Multivariate analysis revealed significantly lower social-emotional development (-14.8 points; P = .05) and adaptive behavior scores (-10.8 points; P < .01) on the Bayley III in children with seizures compared to controls without clinical signs of seizure. Interpretation: Seizures are associated with impaired adaptive behavior and social-emotional development in this cohort of extremely low birth weight infants. These results highlight the negative association between neonatal seizures and functional development.
Databáze:	MEDLINE
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