Higher Dementia Incidence in Older Adults with Poor Visual Acuity.

Autor:	Lee ATC; Department of Psychiatry, The Chinese University of Hong Kong, Hong Kong SAR, China., Richards M; MRC Unit for Lifelong Health and Ageing at UCL, London, UK., Chan WC; Department of Psychiatry, The University of Hong Kong, Hong Kong SAR, China., Chiu HFK; Department of Psychiatry, The Chinese University of Hong Kong, Hong Kong SAR, China., Lee RSY; Elderly Health Service, Department of Health, The Government of Hong Kong SAR, China., Lam LCW; Department of Psychiatry, The Chinese University of Hong Kong, Hong Kong SAR, China.
Jazyk:	angličtina
Zdroj:	The journals of gerontology. Series A, Biological sciences and medical sciences [J Gerontol A Biol Sci Med Sci] 2020 Oct 15; Vol. 75 (11), pp. 2162-2168.
DOI:	10.1093/gerona/glaa036
Abstrakt:	Background: Longitudinal evidence of poor visual acuity associating with higher risk of incident dementia is mixed. This study aimed to examine if poor visual acuity was associated with higher dementia incidence in a large community cohort of older adults, independent of the possible biases relating to misclassification error, reverse causality, and confounding effects due to health problems and behaviors. Methods: A total of 15,576 community-living older adults without dementia at baseline were followed for 6 years to the outcome of incident dementia, which was diagnosed according to the ICD-10 or a Clinical Dementia Rating of 1 to 3. Visual acuity was assessed using the Snellen's chart at baseline and follow-up. Important variables including demographics (age, sex, education, and socioeconomic status), physical and psychiatric comorbidities (cardiovascular risks, ophthalmological conditions, hearing impairment, poor mobility, and depression), and lifestyle behaviors (smoking, diet, physical, intellectual, and social activities) were also assessed. Results: Over 68,904 person-years of follow-up, 1,349 participants developed dementia. Poorer visual acuity at baseline was associated with higher dementia incidence in 6 years, even after adjusting for demographics, health problems, and lifestyle behaviors, and excluding those who developed dementia within 3 years after baseline. Compared with normal vision, the hazard ratio of dementia was 1.19 (p = .31), 2.09 (p < .001), and 8.66 (p < .001) for mild, moderate, and severe visual impairment, respectively. Conclusions: Moderate-to-severe visual impairment could be a potential predictor and possibly a risk factor for dementia. From a clinical perspective, older adults with poor visual acuity might warrant further risk assessment for dementia. (© The Author(s) 2020. Published by Oxford University Press on behalf of The Gerontological Society of America.)
Databáze:	MEDLINE
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