Inverse association between Helicobacter pylori infection and childhood asthma in Greece: a case-control study.

Autor:	Tsigalou C; MD, PhD Laboratory of Microbiology, School of Medicine, Democritus University of Thrace, Dragana 68100, Alexandroupolis, Greece., Konstantinidis TG; MD, PhD Laboratory of Microbiology, School of Medicine, Democritus University of Thrace, Dragana 68100, Alexandroupolis, Greece., Cassimos D; MD, PhD Department of Pediatrics, University General Hospital of Alexandroupolis, Democritus University of Thrace, Dragana 68100, Alexandroupolis, Greece., Karvelas A; MD Laboratory of Microbiology, School of Medicine, Democritus University of Thrace, Dragana 68100, Alexandroupolis, Greece., Grapsa A; MD Laboratory of Microbiology, School of Medicine, Democritus University of Thrace, Dragana 68100, Alexandroupolis, Greece., Tsalkidis A; MD, PhD Department of Pediatrics, University General Hospital of Alexandroupolis, Democritus University of Thrace, Dragana 68100, Alexandroupolis, Greece., Panopoulou M; MD, PhD Laboratory of Microbiology, School of Medicine, Democritus University of Thrace, Dragana 68100, Alexandroupolis, Greece., Tsakris A; MD, PhD Laboratory of Microbiology, Medical School, National and Kapodistrian University of Athens, 75 Mikris Asias, Goudi 115 27, Athens, Greece.
Jazyk:	angličtina
Zdroj:	Germs [Germs] 2019 Dec 02; Vol. 9 (4), pp. 182-187. Date of Electronic Publication: 2019 Dec 02 (Print Publication: 2019).
DOI:	10.18683/germs.2019.1174
Abstrakt:	Introduction: Helicobacter pylori infection is a well-established etiological factor for a variety of diseases such as peptic ulcer and gastric cancer. On the other hand, there is ongoing research suggesting that H. pylori might have a beneficial effect through a pivotal influence in the immunological response especially in asthma. The aim of the current case-control study was to evaluate the prevalence of H. pylori infection in asthmatic children. Methods: Twenty-seven children with exacerbation of persistent asthma, aged 8.6±4.5 years (18 males, 9 females) and 54 age-sex-matched non-asthmatic controls were enrolled. Clinical examination and laboratory investigations were performed. Detection of H. pylori antigen (HpSA) in stool samples was performed by a commercial kit (bioNexia® kit, BioMérieux). Serum specific IgG antibodies were detected by a rapid chromatographic immunoassay (DIAsourceImmunoAssays). Serum IgE concentration was determined by electrochemiluminescence (ECL) (Roche Elecsys) and IgE levels ≥ 90 IU/mL were considered significantly elevated. Results: In 3 (11.1%) of the 27 asthmatic children H. pylori infection (based on both detection of HpSA and specific IgG-Abs) was established, whereas as many as 16 of the 54 (29.6%) non-asthmatic ones were found infected (odds ratio 0.1; 95%CI, 0.039-0.305, p=0.026). Conclusions: Our findings reveal an inverse relationship between H. pylori infection and children's persistent asthma in Greece. Competing Interests: Conflicts of interest: All authors – none to declare. (GERMS.)
Databáze:	MEDLINE
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