Non-invasive prenatal test to screen common trisomies in twin pregnancies.

Autor:	Motevasselian M; 1Men's Health and Reproductive Health Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Saleh Gargari S; 1Men's Health and Reproductive Health Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Younesi S; Prenatal Screening Department of Nilou Laboratory, Tehran, Iran., Pooransari P; 1Men's Health and Reproductive Health Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Saadati P; Prenatal Screening Department of Nilou Laboratory, Tehran, Iran., Mirzamoradi M; 1Men's Health and Reproductive Health Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Savad S; Prenatal Screening Department of Nilou Laboratory, Tehran, Iran., Taheri Amin MM; Prenatal Screening Department of Nilou Laboratory, Tehran, Iran., Modarresi MH; 3Department of Medical Genetics, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran., Afrakhteh M; 1Men's Health and Reproductive Health Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Ghafouri-Fard S; 4Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Jazyk:	angličtina
Zdroj:	Molecular cytogenetics [Mol Cytogenet] 2020 Feb 05; Vol. 13, pp. 5. Date of Electronic Publication: 2020 Feb 05 (Print Publication: 2020).
DOI:	10.1186/s13039-020-0475-8
Abstrakt:	Objectives: Recent years have witnessed a shift from invasive methods of prenatal screening to non-invasive strategies. Accordingly, non-invasive prenatal testing (NIPT) using cell-free fetal DNA in maternal plasma has gained a considerable deal of interest from both geneticists and obstetricians. Efficacy of this method in identification of common aneuploidies has been extensively assessed in singleton pregnancies. However, a limited number of studies have addressed the twin pregnancies. In this context, the present study is aimed at identification of the efficacy of NIPT in twin pregnancies. Methods: NIPT was performed on twin pregnancies to screen trisomies 13, 18 and 21. Pregnant women referring to Nilou Clinical Laboratory between March 2016 and December 2018 were included in this research. Results: In the current study, a total 356 twin pregnancies were screened in search for trisomies 13, 18 and 21. 6 cases exhibited positive NIPT results in which the presence of trisomies 13, 18 and 21 was confirmed by fetal karyotype in 1, 2 and 2 cases, respectively. One twin pregnancy showed normal karyotype. The combined false-positive rate for these trisomies was 0.28%. No false negative case was observed. The combined sensitivity and specificity of NIPT in twin pregnancies were 100 and 99.7%, respectively. Conclusion: The results of the current study verify the feasibility, sensitivity and specificity of NIPT in twin pregnancies. Competing Interests: Competing interestsThe authors declare that they have no competing interests. (© The Author(s). 2020.)
Databáze:	MEDLINE
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