Genotype-independent association between vitamin D deficiency and polycystic ovarian syndrome in Lahore, Pakistan.

Autor: Lone NM; Department of Microbiology and Molecular Genetics, University of the Punjab, Quaid-e-Azam Campus, Lahore, 54590, Pakistan. nasiramunawar@gmail.com.; Institute for Population Health Sciences, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, E1 2AB, UK. nasiramunawar@gmail.com., Riaz S; Department of Microbiology and Molecular Genetics, University of the Punjab, Quaid-e-Azam Campus, Lahore, 54590, Pakistan.; Citilab and Research Center, 525-A Maulana Shaukat Ali Road, Block A Faisal Town, Lahore, 54000, Pakistan., Eusaph AZ; Lady Willingdon Hospital, Ravi Road, Walled City, Lahore, 54000, Pakistan., Mein CA; Genome centre, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, E12AD, UK., Wozniak EL; Genome centre, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, E12AD, UK., Xenakis T; Genome centre, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, E12AD, UK., Wu Z; School of Population Health, The University of Auckland, Auckland, 1142, New Zealand., Younis S; Institute for Population Health Sciences, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, E1 2AB, UK.; Department of Biological Sciences, National University of Medical Sciences, Rawalpindi, 46000, Pakistan., Jolliffe DA; Institute for Population Health Sciences, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, E1 2AB, UK., Junaid K; Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Jouf University, Sakaka, Saudi Arabia., Martineau AR; Institute for Population Health Sciences, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, E1 2AB, UK.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2020 Feb 10; Vol. 10 (1), pp. 2290. Date of Electronic Publication: 2020 Feb 10.
DOI: 10.1038/s41598-020-59228-4
Abstrakt: Both vitamin D deficiency and single nucleotide polymorphisms (SNPs) in the gene encoding the vitamin D receptor (VDR) have been widely reported to associate with susceptibility to polycystic ovarian syndrome (PCOS). A case-control study was conducted to study the influence of vitamin D status and genotpye for 24 SNPs in four genes in the vitamin D pathway (VDR, DBP, CYP27B1, CYP24A1) on PCOS. Statistical analyses were conducted to identify phenotypic and genotypic factors associated with risk of PCOS and to test for interactions between genotype and vitamin D status. PCOS was independently associated with lower age, higher body mass index, lower waist-hip ratio, vitamin D deficiency (serum 25-hydroxyvitamin D concentration <10 ng/mL), lack of outdoor exercise, increased fasting glucose and a family history of PCOS in at least one first degree relative. No statistically significant association was observed between the genotype of any SNP investigated and risk of PCOS, either as a main effect or in interaction with vitamin D status. We report a strong and independent association between vitamin D deficiency and risk of PCOS in Pakistan, that was not modified by genetic variation in the vitamin D pathway.
Databáze: MEDLINE
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