Effect of mild blast-induced TBI on dendritic architecture of the cortex and hippocampus in the mouse.

Autor: Ratliff WA; Bay Pines VA Healthcare System, Research and Development, Bay Pines, FL, USA. whitney.ratliff@va.gov.; NeuroStructural Analytics, Inc., Columbus, OH, USA. whitney.ratliff@va.gov., Mervis RF; NeuroStructural Analytics, Inc., Columbus, OH, USA.; Center for Aging and Brain Repair, Department of Neurosurgery and Brain Repair, University of South Florida Morsani College of Medicine, Tampa, FL, USA., Citron BA; Bay Pines VA Healthcare System, Research and Development, Bay Pines, FL, USA.; VA New Jersey Health Care System, Research & Development, East Orange, NJ, USA.; Department of Pharmacology, Physiology, and Neuroscience, Rutgers- New Jersey Medical School, Newark, NJ, USA., Schwartz B; Department of Anatomy and Anthropology, Tel Aviv University Sackler School of Medicine, Tel Aviv, Israel., Rubovitch V; Department of Anatomy and Anthropology, Tel Aviv University Sackler School of Medicine, Tel Aviv, Israel., Schreiber S; Department of Psychiatry, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.; Department of Psychiatry, Tel Aviv University Sackler School of Medicine, Tel Aviv, Israel.; Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel., Pick CG; Department of Anatomy and Anthropology, Tel Aviv University Sackler School of Medicine, Tel Aviv, Israel.; Department of Psychiatry, Tel Aviv University Sackler School of Medicine, Tel Aviv, Israel.; Dr. Miriam and Sheldon G. Adelson Chair and Center for the Biology of Addictive Diseases, Tel Aviv University, Tel Aviv, Israel.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2020 Feb 10; Vol. 10 (1), pp. 2206. Date of Electronic Publication: 2020 Feb 10.
DOI: 10.1038/s41598-020-59252-4
Abstrakt: Traumatic brain injury (TBI) has been designated as a signature injury of modern military conflicts. Blast trauma, in particular, has come to make up a significant portion of the TBIs which are sustained in warzones. Though most TBIs are mild, even mild TBI can induce long term effects, including cognitive and memory deficits. In our study, we utilized a mouse model of mild blast-related TBI (bTBI) to investigate TBI-induced changes within the cortex and hippocampus. We performed rapid Golgi staining on the layer IV and V pyramidal neurons of the parietal cortex and the CA1 basilar tree of the hippocampus and quantified dendritic branching and distribution. We found decreased dendritic branching within both the cortex and hippocampus in injured mice. Within parietal cortex, this decreased branching was most evident within the middle region, while outer and inner regions resembled that of control mice. This study provides important knowledge in the study of how the shockwave associated with a blast explosion impacts different brain regions.
Databáze: MEDLINE
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