Modeling mesothelioma risk factors from amphibole fiber dimensionality: mineralogical and epidemiological perspective.

Autor: Wylie AG; Laboratory for Mineral Deposits Research, Department of Geology, University of Maryland, College Park, Maryland., Korchevskiy A; Chemistry & Industrial Hygiene, Inc., Wheat Ridge, Colorado., Segrave AM; Bureau Veritas North America, Inc., Kennesaw, Georgia., Duane A; Chemistry & Industrial Hygiene, Inc., Wheat Ridge, Colorado.
Jazyk: angličtina
Zdroj: Journal of applied toxicology : JAT [J Appl Toxicol] 2020 Apr; Vol. 40 (4), pp. 515-524. Date of Electronic Publication: 2020 Feb 10.
DOI: 10.1002/jat.3923
Abstrakt: Amphiboles are common rock-forming minerals but when they form asbestos, they are known carcinogens. Mesothelioma mortality among miners and millers per the unit of asbestiform amphibole exposure varies significantly across cohorts when asbestos exposure measurements are based on the membrane filter method. Because the cohorts were exposed to different occurrences of asbestiform amphibole, variance in mesothelioma potency (R M ) among cohorts is likely due to differences in exposure characteristics not reflected by the membrane filter method. In this paper using both linear and nonlinear models we correlate R M from four mining and milling cohorts with two-dimensional parameters of the exposure. The parameters are based on the proportion of elongated minerals that are >5 μm in length from each occurrence that also have either (a) width ≤ 0.15 μm, or (b) width ≤ 0.25 μm. Based on the models we derived, it was possible to quantify R M for the occurrences of asbestiform amphibole associated with mesothelioma excess but for which epidemiologically based R M has not been published. It was demonstrated that modeled R M for amphibole occurrences in nonasbestiform habits are lower (fibrous glaucophane) or not significant (cleavage fragments). The results of the study can be used in a risk assessment of elongated mineral particles and have implications for public policy and regulations.
(© 2020 John Wiley & Sons, Ltd.)
Databáze: MEDLINE
Externí odkaz: