Brain structural covariance networks in obsessive-compulsive disorder: a graph analysis from the ENIGMA Consortium.

Autor:	Yun JY; Seoul National University Hospital, Seoul, Republic of Korea.; Yeongeon Student Support Center, Seoul National University College of Medicine, Seoul, Republic of Korea., Boedhoe PSW; Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Psychiatry, Amsterdam Neuroscience, Amsterdam, The Netherlands.; Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Anatomy & Neurosciences, Amsterdam Neuroscience, Amsterdam, The Netherlands., Vriend C; Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Psychiatry, Amsterdam Neuroscience, Amsterdam, The Netherlands.; Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Anatomy & Neurosciences, Amsterdam Neuroscience, Amsterdam, The Netherlands., Jahanshad N; Imaging Genetics Center, Mark and Mary Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of the University of Southern California, Marina del Rey, CA, USA., Abe Y; Department of Psychiatry, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan., Ameis SH; The Margaret and Wallace McCain Centre for Child, Youth & Family Mental Health, Campbell Family Mental Health Research Institute, The Centre for Addiction and Mental Health, Department of Psychiatry, Faculty of Medicine, University of Toronto, Toronto, Canada.; Centre for Brain and Mental Health, The Hospital for Sick Children, Toronto, Canada., Anticevic A; Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA., Arnold PD; Mathison Centre for Mental Health Research and Education, Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.; Department of Psychiatry, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada., Batistuzzo MC; Departamento e Instituto de Psiquiatria do Hospital das Clinicas, IPQ HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, SP, Brazil., Benedetti F; Psychiatry and Clinical Psychobiology, Division of Neuroscience, Scientific Institute Ospedale San Raffaele, Milano, Italy., Beucke JC; Department of Psychology, Humboldt-Universität zu Berlin, Berlin, Germany., Bollettini I; Psychiatry and Clinical Psychobiology, Division of Neuroscience, Scientific Institute Ospedale San Raffaele, Milano, Italy., Bose A; Obsessive-Compulsive Disorder (OCD) Clinic Department of Psychiatry National Institute of Mental Health and Neurosciences, Bangalore, India., Brem S; Department of Child and Adolescent Psychiatry and Psychotherapy, Psychiatric Hospital, University of Zurich, Zurich, Switzerland., Calvo A; Magnetic Resonance Image Core Facility, IDIBAPS (Institut d'Investigacions Biomèdiques August Pi i Sunyer), Barcelona, Spain., Cheng Y; Department of Psychiatry, First Affiliated Hospital of Kunming Medical University, Kunming, China., Cho KIK; Institute of Human Behavioral Medicine, SNU-MRC, Seoul, Republic of Korea., Ciullo V; Laboratory of Neuropsychiatry, Department of Clinical and Behavioral Neurology, IRCCS Santa Lucia Foundation, Rome, Italy., Dallaspezia S; Psychiatry and Clinical Psychobiology, Division of Neuroscience, Scientific Institute Ospedale San Raffaele, Milano, Italy., Denys D; Amsterdam UMC, University of Amsterdam, Department of Psychiatry, Amsterdam Neuroscience, Amsterdam, The Netherlands.; Netherlands Institute for Neuroscience, Royal Netherlands Academy of Arts and Sciences, Amsterdam, The Netherlands., Feusner JD; Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA, USA., Fouche JP; SAMRC Unit on Risk and Resilience in Mental Disorders, Department of Psychiatry, University of Cape Town, Cape Town, South Africa., Giménez M; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Carlos III Health Institute, Barcelona, Spain.; Department of Psychiatry, Bellvitge University Hospital, Bellvitge Biomedical Research Institute-IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain., Gruner P; Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA., Hibar DP; Imaging Genetics Center, Mark and Mary Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of the University of Southern California, Marina del Rey, CA, USA., Hoexter MQ; Departamento e Instituto de Psiquiatria do Hospital das Clinicas, IPQ HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, SP, Brazil., Hu H; Shanghai Mental Health Center Shanghai Jiao Tong University School of Medicine, PR China., Huyser C; De Bascule, Academic Center for Child and Adolescent Psychiatry, Amsterdam, The Netherlands.; Amsterdam UMC, Department of Child and Adolescent Psychiatry, Amsterdam, The Netherlands., Ikari K; Department of Neuropsychiatry, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi Higashi-ku, Fukuoka, Japan., Kathmann N; Department of Psychology, Humboldt-Universität zu Berlin, Berlin, Germany., Kaufmann C; Department of Psychology, Humboldt-Universität zu Berlin, Berlin, Germany., Koch K; Department of Neuroradiology, Klinikum rechts der Isar, Technische Universität München, Germany.; TUM-Neuroimaging Center (TUM-NIC) of Klinikum rechts der Isar, Technische Universität München, Germany., Lazaro L; Department of Child and Adolescent Psychiatry and Psychology, Institute of Neurosciences, Hospital Clínic Universitari, Barcelona, Spain.; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.; Department of Medicine, University of Barcelona, Barcelona, Spain.; Centro de Investigación Biomèdica en Red de Salud Mental (CIBERSAM), Barcelona, Spain., Lochner C; SAMRC Unit on Anxiety and Stress Disorders, Department of Psychiatry, University of Stellenbosch, South Africa., Marques P; Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal., Marsh R; Columbia University Medical College, Columbia University, New York, NY, USA.; The New York State Psychiatric Institute, New York, NY, USA., Martínez-Zalacaín I; Department of Psychiatry, Bellvitge University Hospital, Bellvitge Biomedical Research Institute-IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain.; Department of Clinical Sciences, University of Barcelona, Spain., Mataix-Cols D; Department of Clinical Neuroscience, Centre for Psychiatry Research, Karolinska Institutet, Stockholm, Sweden., Menchón JM; Department of Psychiatry, Bellvitge University Hospital, Bellvitge Biomedical Research Institute-IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain.; Centro de Investigación Biomèdica en Red de Salud Mental (CIBERSAM), Barcelona, Spain.; Department of Clinical Sciences, University of Barcelona, Spain., Minuzzi L; McMaster University, Department of Psychiatry and Behavioural Neurosciences, Hamilton, Ontario, Canada., Morgado P; Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal.; Clinical Academic Center-Braga, Braga, Portugal.; ICVS-3Bs PT Government Associate Laboratory, Braga, Portugal., Moreira P; Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal.; Clinical Academic Center-Braga, Braga, Portugal.; ICVS-3Bs PT Government Associate Laboratory, Braga, Portugal., Nakamae T; Department of Psychiatry, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan., Nakao T; Department of Neuropsychiatry, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan., Narayanaswamy JC; Obsessive-Compulsive Disorder (OCD) Clinic Department of Psychiatry National Institute of Mental Health and Neurosciences, Bangalore, India., Nurmi EL; Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA, USA., O'Neill J; Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA, USA.; Division of Child and Adolescent Psychiatry, University of California, Los Angeles, CA, USA., Piacentini J; Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA, USA.; Division of Child and Adolescent Psychiatry, University of California, Los Angeles, CA, USA., Piras F; Laboratory of Neuropsychiatry, Department of Clinical and Behavioral Neurology, IRCCS Santa Lucia Foundation, Rome, Italy., Piras F; Laboratory of Neuropsychiatry, Department of Clinical and Behavioral Neurology, IRCCS Santa Lucia Foundation, Rome, Italy., Reddy YCJ; Obsessive-Compulsive Disorder (OCD) Clinic Department of Psychiatry National Institute of Mental Health and Neurosciences, Bangalore, India., Sato JR; Center for Mathematics, Computing and Cognition, Universidade Federal do ABC, Santo Andre, Brazil., Simpson HB; Columbia University Medical College, Columbia University, New York, NY, USA.; Center for OCD and Related Disorders, New York State Psychiatric Institute, New York, NY, USA., Soreni N; Pediatric OCD Consultation Service, Anxiety Treatment and Research Center, St. Joseph's HealthCare, Hamilton, Ontario, Canada., Soriano-Mas C; Department of Psychiatry, Bellvitge University Hospital, Bellvitge Biomedical Research Institute-IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain.; Centro de Investigación Biomèdica en Red de Salud Mental (CIBERSAM), Barcelona, Spain.; Department of Psychobiology and Methodology of Health Sciences, Universitat Autònoma de Barcelona, Spain., Spalletta G; Laboratory of Neuropsychiatry, Department of Clinical and Behavioral Neurology, IRCCS Santa Lucia Foundation, Rome, Italy.; Beth K. and Stuart C. Yudofsky Division of Neuropsychiatry, Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, Texas, USA., Stevens MC; Yale University School of Medicine, New Haven, Connecticut, USA.; Clinical Neuroscience and Development Laboratory, Olin Neuropsychiatry Research Center, Hartford, Connecticut, USA., Szeszko PR; Icahn School of Medicine at Mount Sinai, New York, USA.; James J. Peters VA Medical Center, Bronx, New York, USA., Tolin DF; Yale University School of Medicine, New Haven, Connecticut, USA.; Institute of Living/Hartford Hospital, Hartford, Connecticut, USA., Venkatasubramanian G; Obsessive-Compulsive Disorder (OCD) Clinic Department of Psychiatry National Institute of Mental Health and Neurosciences, Bangalore, India., Walitza S; Department of Child and Adolescent Psychiatry and Psychotherapy, Psychiatric Hospital, University of Zurich, Zurich, Switzerland., Wang Z; Shanghai Mental Health Center Shanghai Jiao Tong University School of Medicine, PR China.; Shanghai Key Laboratory of Psychotic Disorders, PR China., van Wingen GA; Amsterdam UMC, University of Amsterdam, Department of Psychiatry, Amsterdam Neuroscience, Amsterdam, The Netherlands., Xu J; Department of Psychiatry, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, PR China., Xu X; Department of Psychiatry, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, PR China., Zhao Q; Shanghai Mental Health Center Shanghai Jiao Tong University School of Medicine, PR China., Thompson PM; Imaging Genetics Center, Mark and Mary Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of the University of Southern California, Marina del Rey, CA, USA., Stein DJ; SAMRC Unit on Risk and Resilience in Mental Disorders, Department of Psychiatry, University of Cape Town, Cape Town, South Africa., van den Heuvel OA; Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Psychiatry, Amsterdam Neuroscience, Amsterdam, The Netherlands.; Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Anatomy & Neurosciences, Amsterdam Neuroscience, Amsterdam, The Netherlands., Kwon JS; Department of Psychiatry, Seoul National University College of Medicine, Seoul, Republic of Korea.; Department of Brain and Cognitive Sciences, Seoul National University College of Natural Sciences, Seoul, Republic of Korea.
Jazyk:	angličtina
Zdroj:	Brain : a journal of neurology [Brain] 2020 Feb 01; Vol. 143 (2), pp. 684-700.
DOI:	10.1093/brain/awaa001
Abstrakt:	Brain structural covariance networks reflect covariation in morphology of different brain areas and are thought to reflect common trajectories in brain development and maturation. Large-scale investigation of structural covariance networks in obsessive-compulsive disorder (OCD) may provide clues to the pathophysiology of this neurodevelopmental disorder. Using T1-weighted MRI scans acquired from 1616 individuals with OCD and 1463 healthy controls across 37 datasets participating in the ENIGMA-OCD Working Group, we calculated intra-individual brain structural covariance networks (using the bilaterally-averaged values of 33 cortical surface areas, 33 cortical thickness values, and six subcortical volumes), in which edge weights were proportional to the similarity between two brain morphological features in terms of deviation from healthy controls (i.e. z-score transformed). Global networks were characterized using measures of network segregation (clustering and modularity), network integration (global efficiency), and their balance (small-worldness), and their community membership was assessed. Hub profiling of regional networks was undertaken using measures of betweenness, closeness, and eigenvector centrality. Individually calculated network measures were integrated across the 37 datasets using a meta-analytical approach. These network measures were summated across the network density range of K = 0.10-0.25 per participant, and were integrated across the 37 datasets using a meta-analytical approach. Compared with healthy controls, at a global level, the structural covariance networks of OCD showed lower clustering (P < 0.0001), lower modularity (P < 0.0001), and lower small-worldness (P = 0.017). Detection of community membership emphasized lower network segregation in OCD compared to healthy controls. At the regional level, there were lower (rank-transformed) centrality values in OCD for volume of caudate nucleus and thalamus, and surface area of paracentral cortex, indicative of altered distribution of brain hubs. Centrality of cingulate and orbito-frontal as well as other brain areas was associated with OCD illness duration, suggesting greater involvement of these brain areas with illness chronicity. In summary, the findings of this study, the largest brain structural covariance study of OCD to date, point to a less segregated organization of structural covariance networks in OCD, and reorganization of brain hubs. The segregation findings suggest a possible signature of altered brain morphometry in OCD, while the hub findings point to OCD-related alterations in trajectories of brain development and maturation, particularly in cingulate and orbitofrontal regions. (© The Author(s) (2020). Published by Oxford University Press on behalf of the Guarantors of Brain.)
Databáze:	MEDLINE
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