Gene expression in peripheral blood in treatment-free major depression.

Autor:	Cuellar-Barboza AB; Department of Psychiatry, University Hospital, Universidad Autónoma de Nuevo León, Monterrey, México.; Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN, USA., Sánchez-Ruiz JA; Department of Psychiatry, University Hospital, Universidad Autónoma de Nuevo León, Monterrey, México., Rodriguez-Sanchez IP; Molecular and Structural Physiology Laboratory, School of Biological Sciences, Universidad Autónoma de Nuevo León, Monterrey, México., González S; Department of Psychiatry, University Hospital, Universidad Autónoma de Nuevo León, Monterrey, México., Calvo G; Department of Genetics, University Hospital, Universidad Autónoma de Nuevo León, Monterrey, México., Lugo J; Department of Genetics, University Hospital, Universidad Autónoma de Nuevo León, Monterrey, México., Costilla-Esquivel A; Department of Psychiatry, University Hospital, Universidad Autónoma de Nuevo León, Monterrey, México.; Centro de Investigación en Matemáticas A.C. (CIMAT), Monterrey, México., Martínez LE; Department of Genetics, University Hospital, Universidad Autónoma de Nuevo León, Monterrey, México., Ibarra-Ramirez M; Department of Genetics, University Hospital, Universidad Autónoma de Nuevo León, Monterrey, México.
Jazyk:	angličtina
Zdroj:	Acta neuropsychiatrica [Acta Neuropsychiatr] 2020 Feb 10, pp. 1-10. Date of Electronic Publication: 2020 Feb 10.
DOI:	10.1017/neu.2020.5
Abstrakt:	Background: Peripheral gene expression of several molecular pathways has been studied in major depressive disorder (MDD) with promising results. We sought to investigate some of these genes in a treatment-free Latino sample of Mexican descent. Material and Methods: The sample consisted of 50 MDD treatment-free cases and 50 sex and age-matched controls. Gene expression of candidate genes of neuroplasticity (BDNF, p11, and VGF), inflammation (IL1A, IL1B, IL4, IL6, IL7, IL8, IL10, MIF, and TNFA), the canonical Wnt signaling pathway (TCF7L2, APC, and GSK3B), and mTOR, was compared in cases and controls. RNA was obtained from blood samples. We used bivariate analyses to compare subjects versus control mean mRNA quantification of target genes and lineal regression modelling to test for effects of age and body mass index on gene expression. Results: Most subjects were female (66%) with a mean age of 26.7 (SD 7.9) years. Only GSK3B was differentially expressed between cases and controls at a statistically significant level (p = 0.048). TCF7L-2 showed the highest number of correlations with MDD-related traits, yet these were modest in size. Discussion: GSK3B encodes a moderator of the canonical Wnt signaling pathway. It has a role in neuroplasticity, neuroprotection, depression, and other psychiatric phenotypes. We found that adding population diversity has the potential to elicit distinct peripheral gene expression markers in MDD and MDD-related traits. However, our results should only be considered as hypothesis-generating research that merits further replication in larger cohorts of similar ancestry.
Databáze:	MEDLINE
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