Dietary Restriction and Epigenetics: Part I.

Autor:	Yong-Quan Ng G; Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Yang-Wei Fann D; Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Jo DG; School of Pharmacy, Sungkyunkwan University, Suwon, Republic of Korea., Sobey CG; Department of Physiology, Anatomy & Microbiology, School of Life Sciences, La Trobe University, Bundoora, Victoria, Australia., Arumugam TV; Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.; School of Pharmacy, Sungkyunkwan University, Suwon, Republic of Korea.; Department of Physiology, Anatomy & Microbiology, School of Life Sciences, La Trobe University, Bundoora, Victoria, Australia.
Jazyk:	angličtina
Zdroj:	Conditioning medicine [Cond Med] 2019 Dec; Vol. 2 (6), pp. 284-299.
Abstrakt:	Biological aging occurs concomitantly with chronological aging and is commonly burdened by the development of age-related conditions, such as neurodegenerative, cardiovascular, and a myriad of metabolic diseases. With a current global shift in disease epidemiology associated with aging and the resultant social, economic, and healthcare burdens faced by many countries, the need to achieve successful aging has fueled efforts to address this problem. Aging is a complex biological phenomenon that has confounded much of the historical research effort to understand it, with still limited knowledge of the underlying molecular mechanisms. Interestingly, dietary restriction (DR) is one intervention that produces anti-aging effects from simple organisms to mammals. Research into DR has revealed robust systemic effects that can result in attenuation of age-related diseases via a myriad of molecular mechanisms. Given that numerous age-associated diseases are often polygenic and affect individuals differently, it is possible that they are confounded by interactions between environmental influences and the genome, a process termed 'epigenetics'. In part one of the review, we summarize the different variants of DR regimens and their corresponding mechanism(s) and resultant effects, as well as in-depth analysis of current knowledge of the epigenetic landscape. Competing Interests: Declaration of Conflicting Interests The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
Databáze:	MEDLINE
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