Peripheral Somatosensory Neuron Dysfunction: Emerging Roles in Autism Spectrum Disorders.

Autor: Orefice LL; Department of Molecular Biology, Massachusetts General Hospital and Department of Genetics, Harvard Medical School, 185 Cambridge Street, Boston, MA 02114, USA. Electronic address: orefice@molbio.mgh.harvard.edu.
Jazyk: angličtina
Zdroj: Neuroscience [Neuroscience] 2020 Oct 01; Vol. 445, pp. 120-129. Date of Electronic Publication: 2020 Feb 06.
DOI: 10.1016/j.neuroscience.2020.01.039
Abstrakt: Alterations in somatosensory (touch and pain) behaviors are highly prevalent among people with autism spectrum disorders (ASDs). However, the neural mechanisms underlying abnormal touch and pain-related behaviors in ASDs and how altered somatosensory reactivity might contribute to ASD pathogenesis has not been well studied. Here, we provide a brief review of somatosensory alterations observed in people with ASDs and recent evidence from animal models that implicates peripheral neurons as a locus of dysfunction for somatosensory abnormalities in ASDs. Lastly, we describe current efforts to understand how altered peripheral sensory neuron dysfunction may impact brain development and complex behaviors in ASD models, and whether targeting peripheral somatosensory neurons to improve their function might also improve related ASD phenotypes.
(Copyright © 2020 IBRO. Published by Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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