Variations in hemoglobin measurement and eligibility criteria across blood donation services are associated with differing low-hemoglobin deferral rates: a BEST Collaborative study.

Autor: Zalpuri S; Donor Studies, Department of Donor Medicine Research, Sanquin Research, Amsterdam, The Netherlands., Romeijn B; Donor Studies, Department of Donor Medicine Research, Sanquin Research, Amsterdam, The Netherlands., Allara E; Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom., Goldman M; Medical Services and Innovation, Canadian Blood Services, Ottawa, Ontario, Canada., Kamel H; Vitalant, Scottsdale, Arizona., Gorlin J; Physician Services, Innovative Blood Centers, St. Paul, Minnesota., Vassallo R; Vitalant, Scottsdale, Arizona., Grégoire Y; Medical Affairs and Innovation, Héma-Québec, Quebec City, Canada., Goto N; Safety Vigilance Department, Technical Department, Blood Service Headquarters, Japanese Red Cross Society, Tokyo, Japan., Flanagan P; New Zealand Blood Service, Auckland, New Zealand., Speedy J; Australian Red Cross Blood Service, Adelaide, South Australia, Australia., Buser A; Regional Blood Transfusion Service, Swiss Red Cross, Basel, Switzerland., Kutner JM; Hospital Israelita Albert Einstein, Sao Paulo, Brazil., Magnussen K; Blood Centre and Laboratory Medicine, Innlandet Hospital, Lillehammer, Oppland, Norway., Castrén J; Finnish Red Cross Blood Service, Helsinki, Finland., Culler L; Blood Assurance, Inc, Chattanooga, Tennessee., Sussmann H; Stanford Blood Center, Stanford, California., Prinsze FJ; Donor Studies, Department of Donor Medicine Research, Sanquin Research, Amsterdam, The Netherlands., Belanger K; Shepeard Community Blood Center, Augusta, Georgia., Compernolle V; Red Cross Flanders, Ghent, East Flanders, Belgium., Tiberghien P; Établissement Français du Sang, Paris, Île-de-France, France., Cardenas JM; Centro Vasco de Transfusion y Tejidos Humanos, Galdakao, Biscay, Spain., Gandhi MJ; Division of Transfusion Medicine, Mayo Clinic, Rochester, New York., West KA; National Institutes of Health Clinical Center, Bethesda, Maryland., Lee CK; Hong Kong Red Cross Blood Transfusion Service, Kowloon, Hong Kong SAR, China., James S; Welsh Blood Service, Wales, United Kingdom., Wells D; Community Blood Center of the Carolinas, Charlotte, North Carolina., Sutor LJ; Carter BloodCare, Bedford, Texas., Wendel S; Hospital Sirio Libanes Blood Bank, São Paulo, Brazil., Coleman M; LifeShare Blood Centers, Shreveport, Louisiana., Seltsam A; German Red Cross, Springe, Lower Saxony, Germany., Roden K; Michigan Blood, Saginaw, Michigan., Steele WR; American Red Cross, Washington D.C., Washington., Bohonek M; Military University Hospital Prague, Czech Republic, Prague, Bohemia., Alcantara R; Health Sciences Authority Blood Services Group, Singapore, Singapore., Di Angelantonio E; Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom., van den Hurk K; Donor Studies, Department of Donor Medicine Research, Sanquin Research, Amsterdam, The Netherlands.
Jazyk: angličtina
Zdroj: Transfusion [Transfusion] 2020 Mar; Vol. 60 (3), pp. 544-552. Date of Electronic Publication: 2020 Feb 08.
DOI: 10.1111/trf.15676
Abstrakt: Background: Determination of blood donor hemoglobin (Hb) levels is a pre-requisite to ensure donor safety and blood product quality. We aimed to identify Hb measurement practices across blood donation services and to what extent differences associate with low-Hb deferral rates.
Methods: An online survey was performed among Biomedical Excellence for Safer Transfusion (BEST) Collaborative members, extended with published data. Multivariable negative-binomial regression models were built to estimate adjusted associations of minimum donation intervals, Hb cut-offs (high, ≥13.5 g/dL in men or ≥ 12.5 g/dL in women, vs. lower values), iron monitoring (yes/no), providing or prescribing iron supplementation (yes/no), post-versus pre-donation Hb measurement and geographical location (Asian vs. rest), with low-Hb deferral rates.
Results: Data were included from 38 blood services. Low-Hb deferral rates varied from 0.11% to 8.81% among men and 0.84% to 31.85% among women. Services with longer minimum donation intervals had significantly lower deferral rates among both women (rate ratio, RR 0.53, 95%CI 0.33-0.84) and men (RR 0.53, 95%CI 0.31-0.90). In women, iron supplementation was associated with lower Hb deferral rates (RR 0.47, 95%CI 0.23-0.94). Finally, being located in Asia was associated with higher low-Hb deferral rates; RR 9.10 (95%CI 3.89-21.27) for women and 6.76 (95%CI 2.45-18.68) for men.
Conclusion: Differences in Hb measurement and eligibility criteria, particularly longer donation intervals and iron supplementation in women, are associated with variations in low-Hb deferral rates. These insights could help improve both blood donation service efficiency and donor care.
(© 2020 AABB.)
Databáze: MEDLINE
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