Effect of PET-CT on disease recurrence and management in patients with potentially resectable colorectal cancer liver metastases. Long-term results of a randomized controlled trial.
Autor: | Serrano PE; Department of Surgery, McMaster University, Hamilton, Ontario.; Ontario Clinical Oncology Group, McMaster University, Hamilton, Ontario., Gu CS; Ontario Clinical Oncology Group, McMaster University, Hamilton, Ontario.; Department of Oncology, McMaster University, Hamilton, Ontario., Moulton CA; University Health Network, Toronto, Ontario., Husien M; Grand River Regional Cancer Centre, Kitchener, Ontario., Jalink D; Cancer Centre of Southeastern Ontario at Kingston General Hospital, Kingston, Ontario., Martel G; The Ottawa Hospital, Ottawa, Ontario., Tsang ME; St. Joseph's Health Centre, Toronto, Ontario., Hallet J; Odette Cancer Centre - Sunnybrook Health Sciences Centre, Toronto, Ontario., McAlister V; London Health Sciences Centre, London, Ontario., Gallinger S; University Health Network, Toronto, Ontario., Levine M; Ontario Clinical Oncology Group, McMaster University, Hamilton, Ontario.; Department of Oncology, McMaster University, Hamilton, Ontario. |
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Jazyk: | angličtina |
Zdroj: | Journal of surgical oncology [J Surg Oncol] 2020 May; Vol. 121 (6), pp. 1001-1006. Date of Electronic Publication: 2020 Feb 07. |
DOI: | 10.1002/jso.25864 |
Abstrakt: | Background: Preoperative evaluation of resectable colorectal cancer liver metastases with positron emission tomography (PET) combined with computed tomography (PET-CT) is used extensively. The PETCAM trial evaluated the effect of PET-CT (intervention) vs no PET-CT (control) on surgical management. PET-CT resulted in 8% change in surgical management, therefore, we aimed to compare long-term outcomes (disease-free [DFS], overall survival [OS]). Methods: Trial recruitment (2005-2010) had prospective follow-up until 2013. Events from 2013 to 2017 were collected retrospectively. Survival was described by the Kaplan-Meier method and compared with log-rank test. Oncologic risk factors were calculated using Cox proportional hazard models. Results: Among 404 patients randomized, there were no differences in DFS (hazard ratio [HR] = 1.13; 95% confidence interval [CI], 0.89 to 1.43) or OS (HR, 1.02; 95% CI, 0.78-1.32) between groups. For all patients randomized, median DFS (PET-CT vs no PET-CT) was 16 months (95% CI, 13-18) and 15 months (95% CI, 11-22), P = .33. For patients who underwent liver resection (n = 368), DFS (17 vs 16 months, P = .51) and OS (58 months vs 52 months, P = .90) were similar between groups, respectively. Risk factors for DFS and OS were age, tumor size, node-positive disease, extrahepatic metastases and disease-free duration. Conclusion: Preoperative PET-CT changes surgical management in a small percentage of cases, without effect on recurrence rates or long-term survival. (© 2020 Wiley Periodicals, Inc.) |
Databáze: | MEDLINE |
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