Light-Adapted Electroretinogram Differences in Autism Spectrum Disorder.

Autor: Constable PA; Caring Futures Institute, College of Nursing and Health Sciences, Flinders University, GPO Box 2100, Adelaide, SA, 5001, Australia. Paul.Constable@flinders.edu.au., Ritvo ER; Professor Emeritus, UCLA, Los Angeles, CA, USA., Ritvo AR; Child Study Center, Yale University School of Medicine, New Haven, CT, USA., Lee IO; Behavioural and Brain Sciences Unit, Population Policy and Practice Programme, UCL Great Ormond Street Institute of Child Health, University College London, London, UK., McNair ML; Department of Psychology, Stony Brook University, New York, NY, USA., Stahl D; School of Medicine, Washington University, St Louis, MO, USA., Sowden J; NIHR Great Ormond Street Hospital Biomedical Research Centre, UCL Great Ormond Street Institute of Child Health, University College London, London, UK., Quinn S; Department of Statistics, Data Science and Epidemiology, Swinburne University of Technology, Melbourne, Australia., Skuse DH; Behavioural and Brain Sciences Unit, Population Policy and Practice Programme, UCL Great Ormond Street Institute of Child Health, University College London, London, UK., Thompson DA; The Tony Kriss Visual Electrophysiology Unit, Clinical and Academic Department of Ophthalmology, Great Ormond Street Hospital for Children NHS Trust, London, UK.; UCL Great Ormond Street Institute of Child Health, University College London, London, UK., McPartland JC; Child Study Center, Yale University School of Medicine, New Haven, CT, USA.
Jazyk: angličtina
Zdroj: Journal of autism and developmental disorders [J Autism Dev Disord] 2020 Aug; Vol. 50 (8), pp. 2874-2885.
DOI: 10.1007/s10803-020-04396-5
Abstrakt: Light-adapted (LA) electroretinograms (ERGs) from 90 individuals with autism spectrum disorder (ASD), mean age (13.0 ± 4.2), were compared to 87 control subjects, mean age (13.8 ± 4.8). LA-ERGs were produced by a random series of nine different Troland based, full-field flash strengths and the ISCEV standard flash at 2/s on a 30 cd m -2 white background. A random effects mixed model analysis showed the ASD group had smaller b- and a-wave amplitudes at high flash strengths (p < .001) and slower b-wave peak times (p < .001). Photopic hill models showed the peaks of the component Gaussian (p = .035) and logistic functions (p = .014) differed significantly between groups. Retinal neurophysiology assessed by LA-ERG provides insight into neural development in ASD.
Databáze: MEDLINE
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