| Autor: |
Grimmer G; Biological Institute for Environmental Carcinogens, Grosshansdorf, F.R.G., Brune H, Dettbarn G, Naujack KW, Mohr U, Wenzel-Hartung R |
| Jazyk: |
angličtina |
| Zdroj: |
Cancer letters [Cancer Lett] 1988 Dec 15; Vol. 43 (3), pp. 173-7. |
| DOI: |
10.1016/0304-3835(88)90167-x |
| Abstrakt: |
Particles and semivolatiles from sidestream smoke of cigarettes smoked on a smoking machine were collected by a filter combination consisting of a glass fibre filter and silanized polystyrene beads. The extract of the glass fibre filter was separated by a Sephadex LH-20 column chromatography into a fraction containing non-aromatic material plus polycyclic aromatic compounds (PAC) with 2 and 3 rings and a fraction consisting of PAC with 4 and more rings. To evaluate the carcinogenicity, both fractions as well as the semivolatiles were implanted into the lungs of Osborne-Mendel rats at a dose level of one cigarette per animal and compared with three dose levels of benzo[a]pyrene (BaP). The most pronounced carcinogenic effect of the sidestream smoke (100 ng BaP per cigarette) was caused by the fraction containing polycyclic aromatic hydrocarbons (PAH) with 4 and more rings (5 carcinomas of the lungs/35 rats). This fraction represents only 3.5% by weight of the total sidestream smoke condensate. By contrast, the semivolatile material did not provoke any tumors. Only a small contribution to the total carcinogenicity (1 carcinoma of the lungs/35 rats) was observed for the fraction containing non-aromatic material and 2- and 3-ring PAHs. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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