Cyclin-Dependent Kinase and Antioxidant Gene Expression in Cancers with Poor Therapeutic Response.

Autor: Scaria GS; Research Service, Minneapolis VA Health Care System, Minneapolis, MN 55417, USA., Kren BT; Research Service, Minneapolis VA Health Care System, Minneapolis, MN 55417, USA., Klein MA; Research Service, Minneapolis VA Health Care System, Minneapolis, MN 55417, USA.; Division of Hematology, Oncology and Transplantation, Department of Medicine, University of Minnesota, Minneapolis, MN 55455, USA.; Hematology/Oncology Section, Primary Care Service Line, Minneapolis VA Health Care System, Minneapolis, MN 55417, USA.
Jazyk: angličtina
Zdroj: Pharmaceuticals (Basel, Switzerland) [Pharmaceuticals (Basel)] 2020 Feb 05; Vol. 13 (2). Date of Electronic Publication: 2020 Feb 05.
DOI: 10.3390/ph13020026
Abstrakt: Pancreatic cancer, hepatocellular carcinoma (HCC), and mesothelioma are treatment-refractory cancers, and patients afflicted with these cancers generally have a very poor prognosis. The genomics of these tumors were analyzed as part of The Cancer Genome Atlas (TCGA) project. However, these analyses are an overview and may miss pathway interactions that could be exploited for therapeutic targeting. In this study, the TCGA Pan-Cancer datasets were queried via cBioPortal for correlations among mRNA expression of key genes in the cell cycle and mitochondrial (mt) antioxidant defense pathways. Here we describe these correlations. The results support further evaluation to develop combination treatment strategies that target these two critical pathways in pancreatic cancer, hepatocellular carcinoma, and mesothelioma.
Competing Interests: The authors declare no conflict of interest.
Databáze: MEDLINE
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