Sex differences and higher upper normal limits for left atrial end-systolic volume in individuals in their mid-60s: data from the ACE 1950 Study.

Autor:	Rønningen PS; Department of Medical Research, Bærum Hospital, Vestre Viken Hospital Trust, Postbox 800, 3004 Drammen, Norway.; Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Postbox 1171, Blindern, 0318 Oslo, Norway., Berge T; Department of Medical Research, Bærum Hospital, Vestre Viken Hospital Trust, Postbox 800, 3004 Drammen, Norway., Solberg MG; Department of Medical Research, Bærum Hospital, Vestre Viken Hospital Trust, Postbox 800, 3004 Drammen, Norway.; Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Postbox 1171, Blindern, 0318 Oslo, Norway., Enger S; Department of Medical Research, Bærum Hospital, Vestre Viken Hospital Trust, Postbox 800, 3004 Drammen, Norway., Nygård S; Department of Informatics, Faculty of Mathematics and Natural Sciences, University of Oslo, Postbox 1080, Blindern, 0316 Oslo, Norway., Pervez MO; Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Postbox 1171, Blindern, 0318 Oslo, Norway.; Department of Cardiology, Division of Medicine Akershus University Hospital, Postbox 1000, 1478 Lørenskog, Norway., Orstad EB; Department of Cardiology, Division of Medicine Akershus University Hospital, Postbox 1000, 1478 Lørenskog, Norway., Kvisvik B; Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Postbox 1171, Blindern, 0318 Oslo, Norway.; Department of Cardiology, Division of Medicine Akershus University Hospital, Postbox 1000, 1478 Lørenskog, Norway., Aagaard EN; Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Postbox 1171, Blindern, 0318 Oslo, Norway.; Department of Cardiology, Division of Medicine Akershus University Hospital, Postbox 1000, 1478 Lørenskog, Norway., Røsjø H; Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Postbox 1171, Blindern, 0318 Oslo, Norway.; Division for Research and Innovation, Akershus University Hospital, Postbox 1000, 1478 Lørenskog, Norway., Tveit A; Department of Medical Research, Bærum Hospital, Vestre Viken Hospital Trust, Postbox 800, 3004 Drammen, Norway.; Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Postbox 1171, Blindern, 0318 Oslo, Norway., Steine K; Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Postbox 1171, Blindern, 0318 Oslo, Norway.; Department of Cardiology, Division of Medicine Akershus University Hospital, Postbox 1000, 1478 Lørenskog, Norway.
Jazyk:	angličtina
Zdroj:	European heart journal. Cardiovascular Imaging [Eur Heart J Cardiovasc Imaging] 2020 May 01; Vol. 21 (5), pp. 501-507.
DOI:	10.1093/ehjci/jeaa004
Abstrakt:	Aims: The current study aimed to describe normal values of left atrial (LA) volumes and LA emptying fraction (LAEF) in a large sample in their mid-60s from the general population and to explore sex differences. Methods and Results: In the Akershus Cardiac Examination (ACE) 1950 Study, body surface area-indexed LA maximum (LAVimax) and minimum (LAVimin) volumes and LAEF were measured in 3489 individuals aged 63.9 ± 0.6 years from the general population. A healthy group of 832 individuals was defined. Data are presented as mean ± standard deviation (SD) and a normal range of mean ± 2 SD. T-tests were used for comparisons. In the healthy group, mean LAVimax was 25.5 ± 6.2 mL/m2 and the normal range was 13.1-37.9 mL/m2. Men had significantly larger body surface area-indexed volumes than women, but there was no difference in LAEF. The mean LAVimax for healthy men was 26.4 ± 6.5 mL/m2, for healthy women 24.9 ± 5.8 mL/m2 (P < 0.001) and the upper normal limits were 39.4 and 36.5 mL/m2, respectively. In the healthy group, 13.0% of all men and 5.4% of all women had LAVimax above the current upper normal limit of 34 mL/m2. Conclusion: A large proportion of healthy individuals, in particular men, had LAVimax >34 mL/m2. Our findings suggest that the recommended cut-off may be too low at the age of 65 years and above and that sex-specific cut-offs should be considered. (Published on behalf of the European Society of Cardiology. All rights reserved. © The Author(s) 2020. For permissions, please email: journals.permissions@oup.com.)
Databáze:	MEDLINE
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