| Autor: |
Yousef E; Department of Basic Medical Sciences, College of Medicine, Dar Al Uloom University, Riyadh, KSA, Saudi Arabia. enasesawy@gmail.com.; Histology Department, Faculty of Medicine, Menoufia University, Shebin Elkom, Egypt. enasesawy@gmail.com., Mitwally N; Department of Basic Medical Sciences, College of Medicine, Dar Al Uloom University, Riyadh, KSA, Saudi Arabia., Noufal N; Department of Basic Medical Sciences, College of Medicine, Dar Al Uloom University, Riyadh, KSA, Saudi Arabia.; Pathology Department, Faculty of Medicine, Suez Canal University, Ismailia, Egypt., Tahir MR; Apotex Inc., Toronto, Canada. |
| Abstrakt: |
Shift work with circadian disruption has been considered as a carcinogenic risk factor for skin cancer. The few prior studies that investigated the association between shift work and skin cancer have inconclusive results. Our main objective was to evaluate the associations between shift work and the risks of different types of skin cancer. We systematically searched PubMed, Web of Science, Cochrane Library, EMBASE and Science Direct until October 2018 for studies that included a relationship between shift work and skin cancer. Our search yielded 193 articles and 9 studies met the criteria for our review. The included studies involved 3,579,147 participants and 17,308 skin cancer cases. Overall, ever shift work, was associated with increased risk of melanoma (RR = 1.10, 95% CI = 1.05-1.16) and a significant decrease in the risk of BCC (RR = 0.90, 95% CI = 0.88-0.93). No association between shift work and the risk of SCC was detected. Interestingly, our dose response analysis demonstrated that the risk of melanoma cumulatively increases by 2% for every year of shift work (RR = 1.02; 95% CI = 1.00-1.03). In conclusion, shift work is associated with increased risk of melanoma and deceased risk of BCC. Further studies are needed to confirm our findings and to elucidate the related potential biological mechanisms. |
